Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 7A | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | high affinity cAMP specific 3',5' cyclic | Get druggable targets OG5_133100 | All targets in OG5_133100 |
Echinococcus granulosus | high affinity cAMP specific 3'5' cyclic | Get druggable targets OG5_133100 | All targets in OG5_133100 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.2371 | 0.683 |
Onchocerca volvulus | 0.0231 | 0.4068 | 1 | |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0068 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.3471 | 1 |
Echinococcus granulosus | aminopeptidase N | 0.0231 | 0.4068 | 0.4068 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0068 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0068 | 0 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0068 | 0 | 0.5 |
Entamoeba histolytica | aminopeptidase, putative | 0.0068 | 0 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0068 | 0 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0068 | 0 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0068 | 0 | 0.5 |
Brugia malayi | Peptidase family M1 containing protein | 0.0231 | 0.4068 | 1 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0187 | 0.2968 | 0.8549 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0068 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0068 | 0 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0068 | 0 | 0.5 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0068 | 0 | 0.5 |
Echinococcus multilocularis | high affinity cAMP specific 3',5' cyclic | 0.0468 | 1 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.0231 | 0.4068 | 0.4068 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0068 | 0 | 0.5 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0068 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.88 uM | Inhibition of human recombinant PDE7A1 assessed as inhibition of hydrolysis of [3H]cAMP after 20 mins by scintillation proximity assay | ChEMBL. | 25264825 |
Inhibition (binding) | = 49 % | Inhibition of human recombinant PDE7A1 assessed as inhibition of hydrolysis of [3H]cAMP at 10 uM after 20 mins by scintillation proximity assay | ChEMBL. | 25264825 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.