Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0324 | 0.1203 | 0.1271 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.167 | 0.6762 | 0.6755 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.0641 | 0.0641 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0188 | 0.0641 | 0.0622 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0188 | 0.0641 | 0.0622 |
Loa Loa (eye worm) | glutamate receptor | 0.0784 | 0.3105 | 0.3105 |
Leishmania major | extracellular receptor, putative | 0.0188 | 0.0641 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0037 | 0.002 | 0.002 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0188 | 0.0641 | 0.0768 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.2455 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.0641 | 0.0641 |
Brugia malayi | Guanylyl cyclase protein 23 | 0.0188 | 0.0641 | 0.0768 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.0641 | 0.0641 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0972 | 0.3879 | 0.4777 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.167 | 0.6762 | 0.6755 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.1203 | 0.1203 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0972 | 0.3879 | 0.4183 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.2267 | 0.9226 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0188 | 0.0641 | 0.0622 |
Echinococcus multilocularis | receptor type guanylyl cyclase | 0.0188 | 0.0641 | 0.0622 |
Echinococcus granulosus | tyrosine kinase | 0.0188 | 0.0641 | 0.0622 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0324 | 0.1203 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.0641 | 0.0641 |
Loa Loa (eye worm) | metabotropic glutamate receptor 8 | 0.0188 | 0.0641 | 0.0641 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0188 | 0.0641 | 0.066 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0324 | 0.1203 | 0.1185 |
Schistosoma mansoni | tyrosine kinase | 0.0188 | 0.0641 | 0.066 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0188 | 0.0641 | 0.0768 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0188 | 0.0641 | 0.0622 |
Schistosoma mansoni | protein kinase | 0.0188 | 0.0641 | 0.066 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.001 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0188 | 0.0641 | 0.0622 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0188 | 0.0641 | 0.0641 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0511 | 0.1977 | 0.1977 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0188 | 0.0641 | 0.0641 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.167 | 0.6762 | 0.7319 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0188 | 0.0641 | 0.0622 |
Echinococcus granulosus | receptor type guanylyl cyclase | 0.0188 | 0.0641 | 0.0622 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0324 | 0.1203 | 0.1464 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0188 | 0.0641 | 0.0622 |
Loa Loa (eye worm) | hypothetical protein | 0.2455 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0188 | 0.0641 | 0.0622 |
Loa Loa (eye worm) | glutamate receptor | 0.1994 | 0.8098 | 0.8098 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.0641 | 0.0641 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0188 | 0.0641 | 0.0622 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.1807 | 0.7324 | 0.9042 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0324 | 0.1203 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0188 | 0.0641 | 0.066 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0188 | 0.0641 | 0.0622 |
Echinococcus multilocularis | tyrosine kinase | 0.0188 | 0.0641 | 0.0622 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0324 | 0.1203 | 0.1185 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0511 | 0.1977 | 0.2422 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.1994 | 0.8098 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.001 | 0.5 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0511 | 0.1977 | 0.1977 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0188 | 0.0641 | 0.0641 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0188 | 0.0641 | 0.0622 |
Echinococcus multilocularis | atrial natriuretic peptide receptor | 0.0188 | 0.0641 | 0.0622 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0188 | 0.0641 | 0.0622 |
Brugia malayi | hypothetical protein | 0.0188 | 0.0641 | 0.0768 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.0641 | 0.0641 |
Echinococcus granulosus | atrial natriuretic peptide receptor | 0.0188 | 0.0641 | 0.0622 |
Entamoeba histolytica | hypothetical protein | 0.0188 | 0.0641 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 0.1977 | 0.1977 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.0641 | 0.0641 |
Echinococcus granulosus | glutamate receptor 2 | 0.0188 | 0.0641 | 0.0622 |
Trypanosoma cruzi | extracellular receptor, putative | 0.0188 | 0.0641 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0188 | 0.0641 | 0.0622 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.