Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0725 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0441 | 0.4318 | 0.4318 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0725 | 1 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0441 | 0.4318 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0441 | 0.4318 | 0.5 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0725 | 1 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0725 | 1 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0441 | 0.4318 | 0.5 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0725 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 111 uM | Antibacterial activity against Escherichia coli MG1655 after 20 hrs | ChEMBL. | 19364656 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.