Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | monoamine oxidase B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | amine oxidase, flavin-containing family protein | monoamine oxidase B | 520 aa | 462 aa | 19.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0359 | 0.4787 | 0.5 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0136 | 0.088 | 0.088 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0446 | 0.6319 | 0.6929 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0259 | 0.3042 | 0.3881 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.088 | 0.088 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0532 | 0.7838 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0333 | 0.4343 | 0.5 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0482 | 0.6958 | 0.8878 |
Loa Loa (eye worm) | hypothetical protein | 0.0655 | 1 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0359 | 0.4787 | 0.5 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0136 | 0.088 | 0.1122 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0655 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0605 | 0.912 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0532 | 0.7838 | 0.7838 |
Loa Loa (eye worm) | glutamate receptor | 0.0209 | 0.2162 | 0.2162 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0446 | 0.6319 | 0.6319 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0446 | 0.6319 | 0.6319 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0086 | 0 | 0.5 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0086 | 0 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0259 | 0.3042 | 0.3335 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0136 | 0.088 | 0.088 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of human recombinant MAOA expressed in BTI-TN-5B1-4 cells using p-tyramine substrate assessed as reduction in H2O2 production | ChEMBL. | 25532905 | |
IC50 (binding) | = 2.17 10'3nM | Inhibition of human recombinant MAOB expressed in BTI-TN-5B1-4 cells using p-tyramine substrate assessed as reduction in H2O2 production | ChEMBL. | 25532905 |
Inhibition (binding) | Inhibition of human recombinant MAOA expressed in BTI-TN-5B1-4 cells using p-tyramine substrate assessed as reduction in H2O2 production at 100 uM | ChEMBL. | 25532905 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.