Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.0228 | 1 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0087 | 0.2685 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0166 | 0.6782 | 1 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0087 | 0.2685 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.0228 | 1 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0587 | 0.0865 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0087 | 0.2685 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0087 | 0.2685 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0587 | 0.0865 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0087 | 0.2685 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0228 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0228 | 1 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.0228 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0228 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0228 | 1 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0116 | 0.4201 | 0.6195 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.6782 | 1 |
Echinococcus granulosus | aminopeptidase N | 0.0116 | 0.4201 | 0.6195 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0587 | 0.0865 |
Brugia malayi | Peptidase family M1 containing protein | 0.0116 | 0.4201 | 1 |
Mycobacterium ulcerans | peptide deformylase | 0.0228 | 1 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0087 | 0.2685 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0587 | 0.0865 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.3577 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.2427 | 0.6152 |
Onchocerca volvulus | 0.0116 | 0.4201 | 0.5 | |
Echinococcus granulosus | geminin | 0.0166 | 0.6782 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0587 | 0.1397 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0587 | 0.0865 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0087 | 0.2685 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0587 | 0.0865 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0587 | 0.0865 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.6782 | 1 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0094 | 0.3051 | 0.8238 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 47.65 % | Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production at 5 mg/L pre-incubated for 2 hrs before LPS stimulation for 24 hrs | ChEMBL. | 25453803 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.