Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | peptide deformylase | 0.231 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.231 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.231 | 1 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0881 | 0.3692 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.231 | 1 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0881 | 0.3692 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.231 | 1 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0881 | 0.3692 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0065 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0065 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0881 | 0.3692 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.231 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.0065 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0881 | 0.3692 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0881 | 0.3692 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.231 | 1 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0881 | 0.3692 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.231 | 1 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.0065 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 150 uM | Inhibition of Pseudomonas aeruginosa pseudolysin using Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide as substrate after 15 mins | ChEMBL. | 25462250 |
IC50 (binding) | = 241 uM | Inhibition of Pseudomonas aeruginosa pseudolysin using Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys-(Dnp)-OH as substrate after 1 hr by fluorescence assay in presence of Brij-35 | ChEMBL. | 25462250 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.