Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 | Starlite/ChEMBL | References |
Homo sapiens | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 | Starlite/ChEMBL | References |
Homo sapiens | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium vivax | hypothetical protein, conserved | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 | 231 aa | 188 aa | 21.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0615 | 0.5013 | 1 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0323 | 0.2011 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.084 | 0.0951 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0323 | 0.2011 | 0.1279 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.084 | 0.0951 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0889 | 0.7839 | 0.888 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.1 | 0.1133 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0323 | 0.2011 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.1099 | 1 | 1 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0323 | 0.2011 | 0.2807 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0323 | 0.2011 | 1 |
Entamoeba histolytica | aminopeptidase, putative | 0.0323 | 0.2011 | 0.5 |
Onchocerca volvulus | 0.1099 | 1 | 1 | |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0323 | 0.2011 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.1099 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0615 | 0.5013 | 0.5679 |
Loa Loa (eye worm) | hypothetical protein | 0.0775 | 0.6667 | 0.7552 |
Loa Loa (eye worm) | hypothetical protein | 0.0985 | 0.8828 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0323 | 0.2011 | 0.1279 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0323 | 0.2011 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0615 | 0.5013 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0323 | 0.2011 | 0.1279 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0323 | 0.2011 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0323 | 0.2011 | 0.2807 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0323 | 0.2011 | 0.1279 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0323 | 0.2011 | 0.1279 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0323 | 0.2011 | 0.5 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0615 | 0.5013 | 0.4556 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0323 | 0.2011 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.1132 | 0.1283 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0323 | 0.2011 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0366 | 0.2454 | 0.3867 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0323 | 0.2011 | 0.5 |
Loa Loa (eye worm) | aminopeptidase N | 0.0323 | 0.2011 | 0.2278 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0323 | 0.2011 | 0.1279 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0323 | 0.2011 | 0.5 |
Echinococcus granulosus | small conductance calcium activated potassium | 0.0615 | 0.5013 | 0.3758 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.1 uM | Inhibition of Kca2.2 channel expressed in HEK293 cells by thallium flux assay | ChEMBL. | 18824351 |
IC50 (binding) | = 1.1 uM | Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay | ChEMBL. | 18824351 |
IC50 (binding) | = 1.19 uM | Inhibition of Kca2.1 channel expressed in HEK293 cells by thallium flux assay | ChEMBL. | 18824351 |
IC50 (binding) | = 1.6 uM | Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assay | ChEMBL. | 18824351 |
Inhibition (binding) | = 113 % | Inhibition of Kca2.3 channel expressed in HEK293 cells at 30 uM by thallium flux assay | ChEMBL. | 18824351 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.