Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | calcium:calmodulin dependent 3'5' cyclic | 0.0089 | 0.0974 | 0.1178 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0227 | 0.3202 | 0.7166 |
Onchocerca volvulus | 0.0225 | 0.3174 | 0.9913 | |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0393 | 0.5892 | 1 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0204 | 0.2841 | 0.4822 |
Trichomonas vaginalis | cAMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Trypanosoma brucei | cAMP phosphodiesterase A, putative | 0.0089 | 0.0974 | 0.0449 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0227 | 0.3202 | 0.5175 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0049 | 0.0317 | 0.0481 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0204 | 0.2841 | 0.6957 |
Trichomonas vaginalis | set domain proteins, putative | 0.0225 | 0.3174 | 0.7812 |
Trypanosoma cruzi | cAMP phosphodiesterase A, putative | 0.0089 | 0.0974 | 0.0449 |
Schistosoma mansoni | glycogen phosphorylase | 0.0227 | 0.3202 | 0.477 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0278 | 0.4027 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0646 | 1 | 1 |
Onchocerca volvulus | 0.0204 | 0.2841 | 0.8871 | |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0432 | 0.6534 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0646 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0393 | 0.5892 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0057 | 0.0452 | 0.0827 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0085 | 0.0905 | 0.199 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0393 | 0.5892 | 1 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0278 | 0.4027 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0037 | 0.013 | 0.0406 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0278 | 0.4027 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.004 | 0.0175 | 0.0117 |
Trichomonas vaginalis | chromobox protein, putative | 0.004 | 0.0175 | 0.0117 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0204 | 0.2841 | 0.6957 |
Echinococcus multilocularis | calcium:calmodulin dependent 3',5' cyclic | 0.0089 | 0.0974 | 0.1178 |
Trichomonas vaginalis | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0278 | 0.4027 | 1 |
Trypanosoma cruzi | cAMP phosphodiesterase A, putative | 0.0089 | 0.0974 | 0.0449 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.0049 | 0.0317 | 0.0325 |
Trichomonas vaginalis | cGMP-inhibited 3,5-cyclic phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0111 | 0.1323 | 0.0818 |
Echinococcus multilocularis | calcium:calmodulin dependent 3',5' cyclic | 0.0223 | 0.3139 | 0.5062 |
Giardia lamblia | Glycogen phosphorylase | 0.0227 | 0.3202 | 0.6881 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.034 | 0.5044 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0066 | 0.0601 | 0.0509 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0278 | 0.4027 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.013 | 0.022 |
Brugia malayi | Pre-SET motif family protein | 0.0198 | 0.2732 | 0.4516 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0057 | 0.0452 | 0.0827 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0278 | 0.4027 | 1 |
Loa Loa (eye worm) | PDE1B protein | 0.0223 | 0.3139 | 0.5328 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0278 | 0.4027 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent 3'5' cyclic | 0.0223 | 0.3139 | 0.5062 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0141 | 0.182 | 0.179 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0646 | 1 | 1 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0049 | 0.0317 | 0.0481 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0204 | 0.2841 | 0.5514 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0278 | 0.4027 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0066 | 0.0601 | 0.0818 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0227 | 0.3202 | 0.5175 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0278 | 0.4027 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0159 | 0.2104 | 0.3046 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0227 | 0.3202 | 0.5 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0393 | 0.5892 | 1 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0085 | 0.0905 | 0.0376 |
Echinococcus multilocularis | chromobox protein 1 | 0.0066 | 0.0601 | 0.0509 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0049 | 0.0317 | 0.0481 |
Trypanosoma brucei | RNA helicase, putative | 0.0159 | 0.2104 | 0.1645 |
Schistosoma mansoni | camp/cgmp cyclic nucleotide phosphodiesterase | 0.0085 | 0.0905 | 0.1164 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0204 | 0.2841 | 0.6957 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0198 | 0.2732 | 0.4637 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.0204 | 0.2841 | 0.4705 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0317 | 0.0538 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0136 | 0.1726 | 0.1551 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0114 | 0.1383 | 0.1914 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Echinococcus granulosus | dual 3'5' cyclic AMP and GMP phosphodiesterase | 0.0085 | 0.0905 | 0.1055 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0227 | 0.3202 | 0.5175 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0091 | 0.1001 | 0.0478 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0227 | 0.3202 | 0.7166 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0227 | 0.3202 | 0.7884 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0114 | 0.1383 | 0.1911 |
Loa Loa (eye worm) | cyclic AMP specific phosphodiesterase PDE4D5A | 0.0086 | 0.093 | 0.1578 |
Plasmodium vivax | 3',5'-cyclic nucleotide phosphodiesterase, putative | 0.0089 | 0.0974 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0227 | 0.3202 | 0.7884 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | 0.0049 | 0.0317 | 0.0325 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0085 | 0.0905 | 0.0376 |
Echinococcus granulosus | chromobox protein 1 | 0.0066 | 0.0601 | 0.0509 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0136 | 0.1726 | 0.1551 |
Echinococcus multilocularis | chromobox protein 1 | 0.0066 | 0.0601 | 0.0509 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0114 | 0.1383 | 0.1911 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0204 | 0.2841 | 0.4389 |
Trichomonas vaginalis | cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative | 0.0064 | 0.057 | 0.1129 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0114 | 0.1383 | 0.1911 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0278 | 0.4027 | 1 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Schistosoma mansoni | calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase | 0.0223 | 0.3139 | 0.4671 |
Echinococcus granulosus | glycogen phosphorylase | 0.0227 | 0.3202 | 0.5175 |
Echinococcus multilocularis | dual 3',5' cyclic AMP and GMP phosphodiesterase | 0.0085 | 0.0905 | 0.1055 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0393 | 0.5892 | 0.8992 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Trichomonas vaginalis | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0278 | 0.4027 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0066 | 0.0601 | 0.102 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0204 | 0.2841 | 0.5924 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Schistosoma mansoni | chromobox protein | 0.0066 | 0.0601 | 0.0687 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0091 | 0.1001 | 0.0478 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0063 | 0.055 | 0.1078 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0227 | 0.3202 | 0.5175 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative | 0.0223 | 0.3139 | 0.5223 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0204 | 0.2841 | 0.5924 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0136 | 0.1726 | 0.5 |
Brugia malayi | carbohydrate phosphorylase | 0.0227 | 0.3202 | 0.5332 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.1383 | 0.2347 |
Schistosoma mansoni | chromobox protein | 0.0066 | 0.0601 | 0.0687 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0063 | 0.055 | 0.1078 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.004 | 0.0175 | 0.0548 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0089 | 0.0974 | 0.5609 |
Toxoplasma gondii | hypothetical protein | 0.0104 | 0.1218 | 0.8226 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Schistosoma mansoni | cgmp-dependent 35-cyclic phosphodiesterase | 0.0049 | 0.0317 | 0.0241 |
Trichomonas vaginalis | cAMP/cGMP cyclic nucleotide phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Mycobacterium ulcerans | hypothetical protein | 0.034 | 0.5044 | 1 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Trichomonas vaginalis | chromobox protein, putative | 0.0066 | 0.0601 | 0.1209 |
Trichomonas vaginalis | cAMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0227 | 0.3202 | 1 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0085 | 0.0905 | 0.0376 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0057 | 0.0452 | 0.0827 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.0064 | 0.057 | 0.1129 |
Echinococcus granulosus | glycogen phosphorylase | 0.0227 | 0.3202 | 0.5175 |
Onchocerca volvulus | 0.0039 | 0.0164 | 0.0511 | |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0114 | 0.1383 | 0.1911 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0091 | 0.1001 | 0.0478 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0204 | 0.2841 | 0.6957 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0091 | 0.1001 | 0.0478 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0306 | 0.4484 | 0.4164 |
Trypanosoma brucei | cAMP-specific phosphodiesterase | 0.0085 | 0.0905 | 0.0376 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0227 | 0.3202 | 0.5435 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0086 | 0.093 | 0.1099 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Schistosoma mansoni | glycogen phosphorylase | 0.0227 | 0.3202 | 0.477 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0086 | 0.093 | 0.1099 |
Trypanosoma brucei | cAMP-specific phosphodiesterase | 0.0085 | 0.0905 | 0.0376 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0278 | 0.4027 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0306 | 0.4484 | 0.4164 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.0086 | 0.093 | 0.1388 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0306 | 0.4484 | 0.4164 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0089 | 0.0974 | 0.5609 |
Leishmania major | cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 | 0.0089 | 0.0974 | 0.0449 |
Schistosoma mansoni | glycogen phosphorylase | 0.0098 | 0.1117 | 0.1497 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0204 | 0.2841 | 0.6957 |
Trichomonas vaginalis | chromobox protein, putative | 0.0066 | 0.0601 | 0.1209 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.0085 | 0.0905 | 0.199 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0114 | 0.1383 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0204 | 0.2841 | 0.6957 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0064 | 0.057 | 0.0021 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 89 % | Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM | ChEMBL. | 18930396 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.