Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dynamin | 0.00277886 | 0.811199 | 0.704772 |
Giardia lamblia | Dynamin | 0.00277886 | 0.811199 | 0.5 |
Brugia malayi | Dynamin central region family protein | 0.00277886 | 0.811199 | 0.704772 |
Onchocerca volvulus | 0.00227129 | 0.360491 | 0.5 | |
Echinococcus granulosus | dynamin 1 protein | 0.00277886 | 0.811199 | 0.704772 |
Onchocerca volvulus | 0.00227129 | 0.360491 | 0.5 | |
Entamoeba histolytica | dynamin-1-like protein, putative | 0.00277886 | 0.811199 | 0.5 |
Onchocerca volvulus | 0.00227129 | 0.360491 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.00227129 | 0.360491 | 0.5 |
Onchocerca volvulus | 0.00227129 | 0.360491 | 0.5 | |
Plasmodium vivax | dynamin-like protein, putative | 0.00277886 | 0.811199 | 0.5 |
Plasmodium vivax | dynamin protein, putative | 0.00277886 | 0.811199 | 0.5 |
Trichomonas vaginalis | mgm1, putative | 0.00277886 | 0.811199 | 0.5 |
Trichomonas vaginalis | dynamin, putative | 0.00277886 | 0.811199 | 0.5 |
Trypanosoma cruzi | dynamin-1-like protein | 0.00277886 | 0.811199 | 0.5 |
Onchocerca volvulus | 0.00227129 | 0.360491 | 0.5 | |
Schistosoma mansoni | dynamin | 0.00277886 | 0.811199 | 0.704772 |
Onchocerca volvulus | 0.00227129 | 0.360491 | 0.5 | |
Loa Loa (eye worm) | DRP-1 protein | 0.00277886 | 0.811199 | 0.704772 |
Leishmania major | GTP-binding protein, putative | 0.00277886 | 0.811199 | 0.5 |
Schistosoma mansoni | dynamin | 0.00299148 | 1 | 1 |
Trichomonas vaginalis | dynamin, putative | 0.00277886 | 0.811199 | 0.5 |
Toxoplasma gondii | dynamin-related protein DRPA | 0.00277886 | 0.811199 | 1 |
Onchocerca volvulus | 0.00227129 | 0.360491 | 0.5 | |
Trichomonas vaginalis | dynamin, putative | 0.00277886 | 0.811199 | 0.5 |
Onchocerca volvulus | 0.00227129 | 0.360491 | 0.5 | |
Trichomonas vaginalis | dynamin, putative | 0.00277886 | 0.811199 | 0.5 |
Trichomonas vaginalis | dynamin, putative | 0.00277886 | 0.811199 | 0.5 |
Trichomonas vaginalis | dynamin, putative | 0.00277886 | 0.811199 | 0.5 |
Echinococcus multilocularis | dynamin 1 | 0.00299148 | 1 | 1 |
Brugia malayi | Dynamin | 0.00299148 | 1 | 1 |
Echinococcus granulosus | dynamin 1 | 0.00299148 | 1 | 1 |
Onchocerca volvulus | 0.00227129 | 0.360491 | 0.5 | |
Schistosoma mansoni | dynamin | 0.00299148 | 1 | 1 |
Toxoplasma gondii | dynamin-related protein DRPB | 0.00277886 | 0.811199 | 1 |
Onchocerca volvulus | 0.00227129 | 0.360491 | 0.5 | |
Trypanosoma brucei | dynamin-1-like protein | 0.00277886 | 0.811199 | 0.5 |
Plasmodium falciparum | dynamin-like protein | 0.00277886 | 0.811199 | 0.5 |
Entamoeba histolytica | dynamin-like protein | 0.00277886 | 0.811199 | 0.5 |
Onchocerca volvulus | 0.00227129 | 0.360491 | 0.5 | |
Plasmodium falciparum | dynamin-like protein | 0.00277886 | 0.811199 | 0.5 |
Onchocerca volvulus | 0.00227129 | 0.360491 | 0.5 | |
Echinococcus granulosus | dynamin | 0.00277886 | 0.811199 | 0.704772 |
Onchocerca volvulus | 0.00227129 | 0.360491 | 0.5 | |
Brugia malayi | Dynamin | 0.00299148 | 1 | 1 |
Trichomonas vaginalis | interferon-induced GTP-binding protein mx, putative | 0.00277886 | 0.811199 | 0.5 |
Onchocerca volvulus | 0.00227129 | 0.360491 | 0.5 | |
Trypanosoma brucei | dynamin-1-like protein | 0.00277886 | 0.811199 | 0.5 |
Onchocerca volvulus | 0.00227129 | 0.360491 | 0.5 | |
Onchocerca volvulus | 0.00227129 | 0.360491 | 0.5 | |
Echinococcus multilocularis | dynamin 1 protein | 0.00277886 | 0.811199 | 0.704772 |
Loa Loa (eye worm) | hypothetical protein | 0.00299148 | 1 | 1 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.00227129 | 0.360491 | 0.5 |
Onchocerca volvulus | 0.00227129 | 0.360491 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 7.8 uM | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum FCA 20/ Ghana by [3H]hypoxanthine uptake | ChEMBL. | 12398531 |
IC50 (functional) | = 15.8 uM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2/Indochina by [3H]hypoxanthine uptake | ChEMBL. | 12398531 |
IC50 (functional) | = 16.3 uM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCB1-R/Colombia by [3H]hypoxanthine uptake | ChEMBL. | 12398531 |
IC90 (functional) | = 26.9 uM | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum FCA 20/ Ghana by [3H]hypoxanthine uptake | ChEMBL. | 12398531 |
IC90 (functional) | = 49.7 uM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCB1-R/Colombia by [3H]hypoxanthine uptake | ChEMBL. | 12398531 |
IC90 (functional) | = 52.8 uM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2/Indochina by [3H]hypoxanthine uptake | ChEMBL. | 12398531 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 12398531 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.