Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | transient receptor potential cation channel | 0.00534619 | 0.5 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.00534619 | 0.5 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.00534619 | 0.5 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.00534619 | 0.5 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.00534619 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00534619 | 0.5 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.00534619 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00534619 | 0.5 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.00534619 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00534619 | 0.5 | 0.5 |
Brugia malayi | olfactory channel protein osm-9 | 0.00534619 | 0.5 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.00534619 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 48 uM | Cytotoxicity against human HSC4 cells | ChEMBL. | 20064715 |
CC50 (functional) | = 63 uM | Cytotoxicity against human HL60 cells | ChEMBL. | 20064715 |
CC50 (functional) | = 110 uM | Cytotoxicity against human HSC2 cells | ChEMBL. | 20064715 |
IC50 (functional) | > 2000 ng/ml | Antimalarial activity against drug-resistant Plasmodium falciparum C235 after 72 hrs by SYBR green I staining-based fluorescence assay | ChEMBL. | 24139941 |
IC50 (ADMET) | = 1.58 uM | Cytotoxicity against human HCC2998 cells | ChEMBL. | 16996657 |
IC50 (ADMET) | = 2.29 uM | Cytotoxicity against human SR cells | ChEMBL. | 16996657 |
IC50 (ADMET) | = 3.55 uM | Cytotoxicity against human SW620 cells | ChEMBL. | 16996657 |
IC50 (ADMET) | = 4.37 uM | Cytotoxicity against human K562 cells | ChEMBL. | 16996657 |
IC50 (ADMET) | = 9.98 uM | Cytotoxicity against human CEM cells | ChEMBL. | 16996657 |
IC50 (ADMET) | = 15.8 uM | Cytotoxicity against human COLO205 cells | ChEMBL. | 16996657 |
IC50 (ADMET) | = 19.1 uM | Cytotoxicity against human KM12 cells | ChEMBL. | 16996657 |
IC50 (ADMET) | = 47.9 uM | Cytotoxicity against human HCT116 cells | ChEMBL. | 16996657 |
IC50 (ADMET) | = 49 uM | Cytotoxicity against human HCT15 cells | ChEMBL. | 16996657 |
IC50 (ADMET) | = 103 uM | Cytotoxicity against human mouse L1210 cells | ChEMBL. | 16996657 |
ID50 (functional) | = 4.17 ug ml-1 | Cytocidal activity against human MDR1 gene transfected mouse L5178Y cells after 48 hrs by MTT method | ChEMBL. | 18513966 |
Inhibition (functional) | = 86 % | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv at 6.25 ug/ml by broth microdilution assay | ChEMBL. | 18282710 |
Ratio (binding) | = 133 | Reversal of P-glycoprotein-mediated multidrug resistance in human MDR1 gene transfected mouse L5178Y cells assessed as fluorescence activity ratio at 40 ug/ml by flow cytometry | ChEMBL. | 18513966 |
Ratio (binding) | = 157 | Reversal of P-glycoprotein-mediated multidrug resistance in human MDR1 gene transfected mouse L5178Y cells assessed as fluorescence activity ratio at 4 ug/ml by flow cytometry | ChEMBL. | 18513966 |
Ratio IC50 (functional) | > 1.06 | Ratio of IC50 for drug-resistant Plasmodium falciparum C235 to IC50 for drug-sensitive Plasmodium falciparum D6 | ChEMBL. | 24139941 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 16996657 | |
Plasmodium falciparum | ChEMBL23 | 24139941 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.