Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.00645664 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.00417094 | 0.189114 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.00645664 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.00645664 | 1 | 0.5 |
Leishmania major | p450 reductase, putative | 0.00645664 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.00645664 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.00592357 | 0.810886 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.00645664 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.00645664 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.00417094 | 0.189114 | 0.189114 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.00645664 | 1 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.00645664 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.00645664 | 1 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.00645664 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.00645664 | 1 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.00645664 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.00645664 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.00645664 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.00645664 | 1 | 1 |
Brugia malayi | flavodoxin family protein | 0.00645664 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.00645664 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.00645664 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.00645664 | 1 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.00592357 | 0.810886 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.00645664 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.00645664 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.00645664 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 15 % | Antiplasmodial activity against Plasmodium berghei ANKA infected Fu albino mice (Mus musculus) at 0.01 mL/kg intraperitoneal dose at 24 hrs as parasitaemia per 1000 erythrocytes | ChEMBL. | 19395265 |
IC50 (functional) | = 0.106 uM | Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs as [3H]hypoxanthine uptake | ChEMBL. | 19395265 |
IC50 (functional) | = 0.87 uM | Antitrypanosomal activity against Trypanosoma brucei rhodesiense after 72 hrs by alamar blue assay | ChEMBL. | 19395265 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | 19395265 | ||
Trypanosoma brucei gambiense | 19395265 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.