TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 376.409 | Formula: C21H20N4O3
H donors: 0 H acceptors: 3 LogP: 3.29 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CO/N=C/1\CN([C@H](C1)c1ncno1)C(=O)c1ccc(cc1)c1ccccc1C
InChi: 1S/C21H20N4O3/c1-14-5-3-4-6-18(14)15-7-9-16(10-8-15)21(26)25-12-17(24-27-2)11-19(25)20-22-13-23-28-20/h3-10,13,19H,11-12H2,1-2H3/b24-17-/t19-/m1/s1
InChiKey: AHPMMJNOYVXNON-RJDQKLELSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	oxytocin receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	G protein coupled receptor 139	0.0003	0.004	1
Onchocerca volvulus		0.0003	0.004	0.004
Schistosoma mansoni	neuropeptide F-like receptor	0.0003	0.004	1
Leishmania major	telomerase reverse transcriptase, putative	0.0099	0.2703	1
Brugia malayi	hypothetical protein	0.0003	0.004	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Onchocerca volvulus		0.0003	0.004	0.004
Trichomonas vaginalis	heat shock protein 70 (HSP70)-4, putative	0.0001	0	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0003	0.004	1
Onchocerca volvulus		0.0003	0.004	0.004
Trichomonas vaginalis	microsomal stress 70 protein ATPase core precursor, putative	0.0001	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Plasmodium falciparum	telomerase reverse transcriptase	0.0099	0.2703	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0003	0.004	1
Schistosoma mansoni	opsin-like receptor	0.0003	0.004	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0003	0.004	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0003	0.004	0.0055
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0003	0.004	1
Echinococcus multilocularis	g protein coupled receptor	0.0003	0.004	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0003	0.004	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0003	0.004	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0003	0.004	1
Echinococcus granulosus	fmrfamide receptor	0.0003	0.004	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0003	0.004	0.004
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0003	0.004	1
Echinococcus granulosus	neuropeptide Y receptor	0.0003	0.004	1
Schistosoma mansoni	amine GPCR	0.0003	0.004	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0003	0.004	1
Onchocerca volvulus		0.0003	0.004	0.004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0003	0.004	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Trichomonas vaginalis	heat shock protein, putative	0.0001	0	0.5
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0003	0.004	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0003	0.004	1
Echinococcus granulosus	somatostatin receptor	0.0003	0.004	1
Brugia malayi	hypothetical protein	0.0003	0.004	0.0055
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0003	0.004	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0003	0.004	1
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0099	0.2703	1
Echinococcus multilocularis	neuropeptide receptor	0.0003	0.004	1
Schistosoma mansoni	neuropeptide receptor	0.0003	0.004	1
Entamoeba histolytica	heat shock protein 70 family	0.0001	0	0.5
Onchocerca volvulus		0.0003	0.004	0.004
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0003	0.004	0.0055
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0003	0.004	1
Trypanosoma brucei	telomerase reverse transcriptase	0.0099	0.2703	1
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	0.0001	0	0.5
Brugia malayi	neuropeptide F receptor	0.0003	0.004	0.0055
Onchocerca volvulus		0.0003	0.004	0.004
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0003	0.004	0.0055
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0003	0.004	1
Onchocerca volvulus		0.0003	0.004	0.004
Echinococcus granulosus	g protein coupled receptor	0.0003	0.004	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0003	0.004	1
Brugia malayi	G-protein coupled receptor	0.0003	0.004	0.0055
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0003	0.004	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0003	0.004	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0003	0.004	1
Echinococcus granulosus	g protein coupled receptor	0.0003	0.004	1
Trichomonas vaginalis	heat shock protein, putative	0.0001	0	0.5
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0003	0.004	1
Brugia malayi	GnHR receptor homolog	0.0003	0.004	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Onchocerca volvulus		0.0003	0.004	0.004
Echinococcus granulosus	biogenic amine 5HT receptor	0.0003	0.004	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0003	0.004	1
Entamoeba histolytica	heat shock protein 70, putative	0.0001	0	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0003	0.004	1
Schistosoma mansoni	amine GPCR	0.0003	0.004	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0003	0.004	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Schistosoma mansoni	opsin-like receptor	0.0003	0.004	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0003	0.004	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0003	0.004	1
Brugia malayi	larval opioid receptor	0.0003	0.004	0.0055
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Entamoeba histolytica	70 kDa heat shock protein, putative	0.0001	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0003	0.004	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Onchocerca volvulus		0.0003	0.004	0.004
Echinococcus multilocularis	fmrfamide receptor	0.0003	0.004	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0003	0.004	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0003	0.004	1
Schistosoma mansoni	hypothetical protein	0.0003	0.004	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0003	0.004	1
Echinococcus granulosus	neuropeptide Y receptor	0.0003	0.004	1
Trichomonas vaginalis	heat shock protein, putative	0.0001	0	0.5
Brugia malayi	Telomerase reverse transcriptase	0.0264	0.7258	1
Brugia malayi	G protein-coupled receptor	0.0003	0.004	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Brugia malayi	hypothetical protein	0.0003	0.004	0.0055
Entamoeba histolytica	hypothetical protein	0.0001	0	0.5
Trichomonas vaginalis	heat shock protein 70kD, putative	0.0001	0	0.5
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0003	0.004	1
Trichomonas vaginalis	heat shock protein 70 (HSP70)-4, putative	0.0001	0	0.5
Brugia malayi	hypothetical protein	0.0003	0.004	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0003	0.004	1
Echinococcus granulosus	orexin receptor type 2	0.0003	0.004	1
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	0.0001	0	0.5
Brugia malayi	Melatonin receptor type 1A	0.0003	0.004	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0003	0.004	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0003	0.004	1
Trichomonas vaginalis	heat shock protein, putative	0.0001	0	0.5
Echinococcus granulosus	7tm_1 domain containing protein	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Brugia malayi	Dopamine receptor	0.0003	0.004	0.0055
Schistosoma mansoni	biogenic amine receptor	0.0003	0.004	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0003	0.004	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0003	0.004	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0003	0.004	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0003	0.004	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0003	0.004	1
Onchocerca volvulus		0.0003	0.004	0.004
Echinococcus multilocularis	neuropeptide s receptor	0.0003	0.004	1
Echinococcus granulosus	serotonin receptor	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Brugia malayi	hypothetical protein	0.0003	0.004	0.0055
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0003	0.004	1
Onchocerca volvulus		0.0003	0.004	0.004
Echinococcus granulosus	g protein coupled receptor	0.0003	0.004	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0003	0.004	1
Onchocerca volvulus		0.0003	0.004	0.004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0003	0.004	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Schistosoma mansoni	histamine h1 receptor	0.0003	0.004	1
Brugia malayi	AKH receptor	0.0003	0.004	0.0055
Echinococcus multilocularis	serotonin receptor	0.0003	0.004	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0003	0.004	0.0055
Schistosoma mansoni	hypothetical protein	0.0003	0.004	1
Entamoeba histolytica	heat shock protein 70, putative	0.0001	0	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0003	0.004	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0003	0.004	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0003	0.004	1
Schistosoma mansoni	amine GPCR	0.0003	0.004	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0003	0.004	1
Trichomonas vaginalis	heat shock protein, putative	0.0001	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Echinococcus granulosus	hypothetical protein	0.0003	0.004	1
Schistosoma mansoni	amine GPCR	0.0003	0.004	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0003	0.004	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0003	0.004	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0003	0.004	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0003	0.004	1
Schistosoma mansoni	opsin-like receptor	0.0003	0.004	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0003	0.004	1
Schistosoma mansoni	neuropeptide receptor	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Schistosoma mansoni	hypothetical protein	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	0.0001	0	0.5
Toxoplasma gondii	RNA-directed DNA polymerase	0.0099	0.2703	1
Schistosoma mansoni	biogenic amine receptor	0.0003	0.004	1
Trichomonas vaginalis	heat shock protein, putative	0.0001	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Trichomonas vaginalis	heat shock protein, putative	0.0001	0	0.5
Brugia malayi	sulfakinin receptor protein	0.0003	0.004	0.0055
Echinococcus granulosus	rhodopsin orphan GPCR	0.0003	0.004	1
Brugia malayi	putative neuropeptide receptor	0.0003	0.004	0.0055
Echinococcus multilocularis	g protein coupled receptor	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Echinococcus multilocularis	neuropeptide receptor	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Echinococcus multilocularis	serotonin receptor	0.0003	0.004	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0003	0.004	0.0055
Schistosoma mansoni	growth hormone secretagogue receptor	0.0003	0.004	1
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0099	0.2703	1
Entamoeba histolytica	heat shock protein 70 family	0.0001	0	0.5
Brugia malayi	ORL1-like opioid receptor	0.0003	0.004	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0003	0.004	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0003	0.004	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0003	0.004	1
Schistosoma mansoni	neuropeptide receptor	0.0003	0.004	1
Brugia malayi	G-protein coupled receptor	0.0003	0.004	0.0055
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0003	0.004	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0003	0.004	1
Schistosoma mansoni	myosin xvIII	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0003	0.004	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Trichomonas vaginalis	heat shock protein, putative	0.0001	0	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0003	0.004	1
Trichomonas vaginalis	heat shock protein 70 (HSP70)-4, putative	0.0001	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Schistosoma mansoni	biogenic amine receptor	0.0003	0.004	1
Schistosoma mansoni	amine GPCR	0.0003	0.004	1
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	0.0001	0	0.5
Entamoeba histolytica	heat shock protein 70, putative	0.0001	0	0.5
Brugia malayi	hypothetical protein	0.0003	0.004	0.0055
Brugia malayi	Dopamine receptor protein 1	0.0003	0.004	0.0055
Brugia malayi	hypothetical protein	0.0003	0.004	0.0055
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0003	0.004	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0003	0.004	0.0055
Brugia malayi	Serotonin receptor	0.0003	0.004	0.0055
Loa Loa (eye worm)	TYRA-2 protein	0.0003	0.004	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0003	0.004	1
Echinococcus granulosus	neuropeptides capa receptor	0.0003	0.004	1
Schistosoma mansoni	hypothetical protein	0.0003	0.004	1
Echinococcus granulosus	neuropeptide receptor	0.0003	0.004	1
Echinococcus multilocularis	allatostatin A receptor	0.0003	0.004	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0003	0.004	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0003	0.004	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0003	0.004	1
Onchocerca volvulus		0.0003	0.004	0.004
Echinococcus multilocularis	orexin receptor type 2	0.0003	0.004	1
Brugia malayi	follicle stimulating hormone receptor	0.0003	0.004	0.0055
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0003	0.004	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0003	0.004	1
Echinococcus granulosus	neuropeptide s receptor	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0003	0.004	1
Brugia malayi	neuropeptide F receptor	0.0003	0.004	0.0055
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0003	0.004	0.004
Brugia malayi	Dopamine receptor protein 2	0.0003	0.004	0.0055
Echinococcus multilocularis	neuropeptide receptor A26	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Echinococcus multilocularis	g protein coupled receptor	0.0003	0.004	1
Brugia malayi	hypothetical protein	0.0003	0.004	0.0055
Echinococcus multilocularis	somatostatin receptor	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Echinococcus multilocularis	fmrfamide receptor	0.0003	0.004	1
Schistosoma mansoni	adenoreceptor	0.0003	0.004	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0003	0.004	1
Onchocerca volvulus		0.0003	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Echinococcus granulosus	neuropeptide receptor	0.0003	0.004	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0003	0.004	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0003	0.004	1
Onchocerca volvulus		0.0003	0.004	0.004
Trichomonas vaginalis	heat shock protein, putative	0.0001	0	0.5
Brugia malayi	hypothetical protein	0.0003	0.004	0.0055
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0003	0.004	1
Echinococcus granulosus	sex peptide receptor	0.0003	0.004	1
Onchocerca volvulus		0.0003	0.004	0.004
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0003	0.004	1
Echinococcus multilocularis	sex peptide receptor	0.0003	0.004	1
Onchocerca volvulus		0.0003	0.004	0.004
Plasmodium vivax	telomerase reverse transcriptase, putative	0.0099	0.2703	1
Echinococcus multilocularis	g-protein coupled receptor	0.0003	0.004	1
Brugia malayi	Serotonin receptor	0.0003	0.004	0.0055
Entamoeba histolytica	heat shock protein 70, putative	0.0001	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Giardia lamblia	Telomerase catalytic subunit	0.0099	0.2703	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0003	0.004	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0003	0.004	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0003	0.004	1
Echinococcus granulosus	g-protein coupled receptor	0.0003	0.004	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0003	0.004	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0003	0.004	1
Echinococcus granulosus	allatostatin A receptor	0.0003	0.004	1
Echinococcus granulosus	neuropeptide receptor A26	0.0003	0.004	1
Brugia malayi	hypothetical protein	0.0003	0.004	0.0055
Schistosoma mansoni	neuropeptide receptor	0.0003	0.004	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0003	0.004	1
Brugia malayi	RE15519p	0.0003	0.004	0.0055
Trichomonas vaginalis	heat shock protein 70kD, putative	0.0001	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.004	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0003	0.004	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0003	0.004	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0003	0.004	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (functional)	= 50 nM	Antagonist activity at human cloned oxytocin receptor by cell based beta lactamase reporter assay	ChEMBL.	18639455

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL467153

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 971917