Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0041 | 0.1471 | 0.0699 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0041 | 0.1471 | 0.0699 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0046 | 0.1684 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0041 | 0.1471 | 0.0699 |
Onchocerca volvulus | 0.0029 | 0.083 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.2615 | 0.1947 |
Schistosoma mansoni | calcium-activated potassium channel | 0.021 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2986 | 0.2351 |
Schistosoma mansoni | hypothetical protein | 0.021 | 1 | 1 |
Onchocerca volvulus | 0.0029 | 0.083 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 1 | 1 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.021 | 1 | 1 |
Onchocerca volvulus | 0.0029 | 0.083 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0.083 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0.083 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0.083 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0029 | 0.083 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0029 | 0.083 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0136 | 0.6229 | 0.5888 |
Onchocerca volvulus | 0.0029 | 0.083 | 0.5 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.1664 | 0.091 |
Onchocerca volvulus | 0.0029 | 0.083 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0.083 | 0.5 | |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0046 | 0.1684 | 1 |
Onchocerca volvulus | 0.0029 | 0.083 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0.083 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0.083 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0.083 | 0.5 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.1664 | 0.091 |
Onchocerca volvulus | 0.0029 | 0.083 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1194 | 0.0397 |
Onchocerca volvulus | 0.0029 | 0.083 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0.083 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.279 | 0.2138 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0041 | 0.1471 | 1 |
Onchocerca volvulus | 0.0029 | 0.083 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.9 uM | Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay | ChEMBL. | 18824351 |
Inhibition (binding) | = 96 % | Inhibition of Kca2.3 channel expressed in HEK293 cells at 30 uM by thallium flux assay | ChEMBL. | 18824351 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.