Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0915 | 0.507 | 0.507 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0407 | 0.0043 | 0.0043 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0915 | 0.507 | 0.5048 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0407 | 0.0043 | 0.5 |
Giardia lamblia | Kinase, CMGC CDK | 0.0407 | 0.0043 | 0.5 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0407 | 0.0043 | 0.5 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0407 | 0.0043 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0407 | 0.0043 | 0.0043 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0407 | 0.0043 | 0.5 |
Plasmodium falciparum | protein kinase 5 | 0.0407 | 0.0043 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0407 | 0.0043 | 0.0043 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0915 | 0.507 | 0.5048 |
Brugia malayi | Trypsin family protein | 0.0915 | 0.507 | 1 |
Plasmodium vivax | protein kinase Crk2 | 0.0407 | 0.0043 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1414 | 1 | 1 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0407 | 0.0043 | 0.5 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0407 | 0.0043 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0407 | 0.0043 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0407 | 0.0043 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0677 | 0.2712 | 0.2712 |
Brugia malayi | hypothetical protein | 0.0677 | 0.2712 | 0.5311 |
Echinococcus multilocularis | cyclin dependent kinase 5 activator 1 | 0.1414 | 1 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0407 | 0.0043 | 0.5 |
Onchocerca volvulus | 0.0915 | 0.507 | 1 | |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0407 | 0.0043 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0407 | 0.0043 | 0.5 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0435 | 0.0324 | 0.0559 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0407 | 0.0043 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0677 | 0.2712 | 0.2712 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0435 | 0.0324 | 0.0324 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0407 | 0.0043 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0407 | 0.0043 | 0.5 |
Giardia lamblia | Kinase, CMGC CDK | 0.0407 | 0.0043 | 0.5 |
Schistosoma mansoni | cyclin-dependent kinase 5 activator | 0.1414 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0915 | 0.507 | 0.507 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | > 30 uM | Activation of flag-tagged human recombinant liver glucokinase expressed in Escherichia coli by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 2.5 mM glucose | ChEMBL. | 19282189 |
EC50 (binding) | > 30 uM | Activation of flag-tagged human recombinant liver glucokinase expressed in Escherichia coli by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 10 mM glucose | ChEMBL. | 19282189 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.