TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 372.379 | Formula: C17H20N6O4
H donors: 5 H acceptors: 6 LogP: -0.09 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1c(NCc2ccccc2)nc2c1ncnc2N
InChi: 1S/C17H20N6O4/c18-14-11-15(21-8-20-14)23(16-13(26)12(25)10(7-24)27-16)17(22-11)19-6-9-4-2-1-3-5-9/h1-5,8,10,12-13,16,24-26H,6-7H2,(H,19,22)(H2,18,20,21)/t10-,12-,13-,16-/m1/s1
InChiKey: XBPUFDODTYBKPH-XNIJJKJLSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	heat shock 70kDa protein 8	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Theileria parva	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein 70kD, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 71 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei gambiense	glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70b	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70 family	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	Cytoplasmic chaperone	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei	heat shock protein 70 (hsp70), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma mansoni	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania donovani	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma mansoni	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania major	heat shock protein 70-related protein	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium yoelii	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	glucose-regulated protein 78, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock kda protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma cruzi	heat shock protein 70 (hsp70), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70 related	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania braziliensis	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Babesia bovis	dnaK protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70 related	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis		Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania braziliensis	heat shock protein 70-related protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat Shock protein family member (hsp 3)	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei	luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	similar to Heat shock 70 kDa protein cognate 4, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock kda protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein kDa	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania mexicana	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma cruzi	heat shock protein 70 (hsp70), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Cryptosporidium hominis	heat shock protein 70 precursor	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis		Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium knowlesi	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 71 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Brugia malayi	heat shock 70 kDa protein C precursor	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	HSP70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70b	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium berghei	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70 family	Get druggable targets OG5_126588	All targets in OG5_126588
Brugia malayi	heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Toxoplasma gondii	heat shock protein HSP70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Babesia bovis	heat shock protein 70 precursor, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania mexicana	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock 70 kda protein 1a	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	3'partial\|5'partial\|heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium vivax	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium knowlesi	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei	luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium vivax	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Onchocerca volvulus		Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	heat shock protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein 70kD, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Toxoplasma gondii	chaperonin protein BiP	Get druggable targets OG5_126588	All targets in OG5_126588
Cryptosporidium hominis	heat shock protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70 related	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Neospora caninum	Heat shock protein 70 (Precursor), related	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania donovani	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	similar to Heat shock 70 kDa protein homolog, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein kDa heat shock kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock 70 kDa protein 1A:1B	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei gambiense	glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein kDa heat shock kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Giardia lamblia	Cytosolic HSP70	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium falciparum	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	70 kDa heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium falciparum	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania donovani	heat shock protein 70-related protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis		Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein 70 (HSP70)-4, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock 70 kDa protein 1	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	heat shock protein 70-related protein	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium berghei	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70 related	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock protein 70 (HSP70)	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania major	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Neospora caninum	Heat shock protein 70, related	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania mexicana	glucose-regulated protein 78, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Cryptosporidium parvum	heat shock protein, Hsp70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	microsomal stress 70 protein ATPase core precursor, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma mansoni	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania major	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Giardia lamblia	Bip	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 71 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium yoelii	heat shock protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein 70 (HSP70)-4, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat Shock protein family member hsp 3	Get druggable targets OG5_126588	All targets in OG5_126588
Theileria parva	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania major	glucose-regulated protein 78, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania donovani	luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma cruzi	glucose-regulated protein 78, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania mexicana	heat shock protein 70-related protein	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	Cytoplasmic chaperone	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium falciparum	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Cryptosporidium parvum	heat shock 70 (HSP70) protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Loa Loa (eye worm)	heat shock 70kDa protein 5	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	HSP70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei gambiense	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 71 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania braziliensis	glucose-regulated protein 78, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein 70 (HSP70)-4, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	ko:K09490 heat shock 70kDa protein 5, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	heat shock protein 70	heat shock 70kDa protein 8	646 aa	577 aa	51.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	heat shock protein 70	0.0002	0	0.5
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	0.0002	0	0.5
Trichomonas vaginalis	heat shock protein, putative	0.0002	0	0.5
Trichomonas vaginalis	heat shock protein, putative	0.0002	0	0.5
Echinococcus multilocularis	sodium bile acid cotransporter	0.0205	1	1
Trichomonas vaginalis	heat shock protein, putative	0.0002	0	0.5
Entamoeba histolytica	heat shock protein 70, putative	0.0002	0	0.5
Echinococcus multilocularis	sodium bile acid cotransporter	0.0205	1	1
Echinococcus granulosus	sodium bile acid cotransporter	0.0205	1	1
Toxoplasma gondii	heat shock protein HSP70	0.0002	0	0.5
Trichomonas vaginalis	heat shock protein 70kD, putative	0.0002	0	0.5
Echinococcus granulosus	sodium bile acid cotransporter	0.0205	1	1
Entamoeba histolytica	hypothetical protein	0.0002	0	0.5
Echinococcus granulosus	sodium bile acid cotransporter	0.0205	1	1
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	0.0002	0	0.5
Plasmodium vivax	heat shock protein 70, putative	0.0002	0	0.5
Trichomonas vaginalis	heat shock protein 70 (HSP70)-4, putative	0.0002	0	0.5
Schistosoma mansoni	sodium-bile acid cotransporter related	0.0083	0.4003	0.4003
Leishmania major	heat-shock protein hsp70, putative	0.0002	0	0.5
Trypanosoma brucei	luminal binding protein 1 (BiP), putative	0.0002	0	0.5
Trichomonas vaginalis	heat shock protein, putative	0.0002	0	0.5
Plasmodium falciparum	heat shock protein 70	0.0002	0	0.5
Leishmania major	heat shock protein 70-related protein	0.0002	0	0.5
Trichomonas vaginalis	heat shock protein, putative	0.0002	0	0.5
Giardia lamblia	Cytosolic HSP70	0.0002	0	0.5
Trypanosoma cruzi	heat shock protein 70 (hsp70), putative	0.0002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0205	1	1
Trichomonas vaginalis	heat shock protein, putative	0.0002	0	0.5
Entamoeba histolytica	heat shock protein 70, putative	0.0002	0	0.5
Onchocerca volvulus		0.0205	1	1
Trichomonas vaginalis	heat shock protein 70 (HSP70)-4, putative	0.0002	0	0.5
Giardia lamblia	Bip	0.0002	0	0.5
Entamoeba histolytica	heat shock protein 70, putative	0.0002	0	0.5
Trichomonas vaginalis	heat shock protein 70 (HSP70)-4, putative	0.0002	0	0.5
Schistosoma mansoni	sodium-bile acid cotransporter	0.0122	0.591	0.591
Trichomonas vaginalis	heat shock protein 70kD, putative	0.0002	0	0.5
Trypanosoma brucei	heat shock protein 70 (hsp70), putative	0.0002	0	0.5
Plasmodium vivax	heat shock 70 kDa protein, putative	0.0002	0	0.5
Trichomonas vaginalis	heat shock protein, putative	0.0002	0	0.5
Trichomonas vaginalis	heat shock protein, putative	0.0002	0	0.5
Trichomonas vaginalis	microsomal stress 70 protein ATPase core precursor, putative	0.0002	0	0.5
Trypanosoma brucei	luminal binding protein 1 (BiP), putative	0.0002	0	0.5
Entamoeba histolytica	heat shock protein 70 family	0.0002	0	0.5
Trichomonas vaginalis	heat shock protein, putative	0.0002	0	0.5
Schistosoma mansoni	sodium-bile acid cotransporter related	0.0205	1	1
Leishmania major	glucose-regulated protein 78, putative	0.0002	0	0.5
Trypanosoma cruzi	heat shock protein 70 (hsp70), putative	0.0002	0	0.5
Entamoeba histolytica	70 kDa heat shock protein, putative	0.0002	0	0.5
Toxoplasma gondii	chaperonin protein BiP	0.0002	0	0.5
Entamoeba histolytica	heat shock protein 70 family	0.0002	0	0.5
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	0.0002	0	0.5
Trypanosoma brucei	heat shock 70 kDa protein, putative	0.0002	0	0.5
Trypanosoma brucei	heat shock protein 70	0.0002	0	0.5
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	0.0002	0	0.5
Echinococcus multilocularis	sodium bile acid cotransporter	0.0205	1	1
Entamoeba histolytica	heat shock protein 70, putative	0.0002	0	0.5
Plasmodium falciparum	heat shock protein 70	0.0002	0	0.5
Leishmania major	heat-shock protein hsp70, putative	0.0002	0	0.5
Trypanosoma cruzi	glucose-regulated protein 78, putative	0.0002	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	> 80 uM	Cytotoxicity against human HCT116 cells by SRB assay	ChEMBL.	19256508
IC50 (binding)	= 52 uM	Inhibition of human CNT2 expressed in COS7 cells assessed as reduction in sodium-dependent [14C]-inosine uptake in presence of Na+ by liquid scintillation counting method	ChEMBL.	25815140
Inhibition (binding)	= 58 %	Inhibition of human CNT2 expressed in COS7 cells assessed as reduction in sodium-dependent [14C]-inosine uptake at 100 uM in presence of Na+ by liquid scintillation counting method	ChEMBL.	25815140
Inhibition (binding)	= 100 %	Inhibition of Leishmania mexicana GAPDH(glyceraldehyde-3-phosphate dehydrogenase)	ChEMBL.	9934461
Kd (binding)	= 5.84	Binding affinity to human truncated HSC70 NBD (1 to 381 residues) by SPR analysis	ChEMBL.	27119979
Kd (binding)	= 1.4 uM	Binding affinity to human truncated HSC70 NBD (1 to 381 residues) by SPR analysis	ChEMBL.	27119979

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL473365

Bibliographic References

3 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 974319