Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0522 | 0.4071 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0522 | 0.4071 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0288 | 0.0087 | 0.0214 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0288 | 0.0087 | 0.0214 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0288 | 0.0087 | 0.0214 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0288 | 0.0087 | 0.0214 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.087 | 1 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.087 | 1 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0522 | 0.4071 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.087 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.087 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0288 | 0.0087 | 0.0214 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0288 | 0.0087 | 0.0214 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0288 | 0.0087 | 0.0214 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0288 | 0.0087 | 0.0214 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0288 | 0.0087 | 0.0214 |
Echinococcus granulosus | glutamate receptor 2 | 0.0288 | 0.0087 | 0.0214 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 60 % | Inhibition of bovine Xanthine oxidase assessed as reduction in uric acid level at 10 ug/ml by spectrophotometry | ChEMBL. | 21620698 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.