Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0111 | 0.006 | 0.4538 |
Mycobacterium ulcerans | thymidine phosphorylase | 1.0733 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0 | 0.5 |
Echinococcus multilocularis | protein dispatched 1 | 0.0053 | 0.0006 | 0.0006 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | 1.0733 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.0132 | 1 |
Mycobacterium tuberculosis | Probable anthranilate phosphoribosyltransferase TrpD | 0.3029 | 0.2791 | 0.2648 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0109 | 0.0058 | 1 |
Echinococcus granulosus | expressed conserved protein | 0.0102 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0058 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0156 | 0.0102 | 0.0102 |
Echinococcus multilocularis | geminin | 0.0188 | 0.0132 | 0.0132 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0109 | 0.0058 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0156 | 0.0102 | 0.0102 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0109 | 0.0058 | 0.0058 |
Echinococcus multilocularis | expressed conserved protein | 0.0102 | 0.0052 | 0.0052 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0109 | 0.0058 | 0.0058 |
Mycobacterium leprae | Probable anthranilate phosphoribosyltransferase TrpD | 0.3029 | 0.2791 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.0132 | 1 |
Echinococcus multilocularis | thymidine phosphorylase | 1.0733 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.001 | 0.1691 |
Echinococcus granulosus | geminin | 0.0188 | 0.0132 | 0.0132 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.