Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | steroid hormone receptor | 0.0364646 | 1 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0324 | 0.5217 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0285256 | 0 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0364646 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0317 | 0.4783 | 0.9147 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0324 | 0.5217 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0239 | 0 | 0.5 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Leishmania donovani | ChEMBL23 | 19091562 | |
Plasmodium falciparum | 19091562 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.