Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | squalene synthase, putative | 0.034 | 0.649 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0162 | 0.1475 | 1 |
Brugia malayi | geranylgeranyl pyrophosphate synthetase | 0.0109 | 0 | 0.5 |
Echinococcus granulosus | Squalene phytoene synthase | 0.0162 | 0.1475 | 1 |
Leishmania major | squalene synthase, putative | 0.034 | 0.649 | 1 |
Trypanosoma cruzi | squalene synthase, putative | 0.034 | 0.649 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0162 | 0.1475 | 0.2273 |
Trypanosoma brucei | squalene synthase, putative | 0.034 | 0.649 | 0.5 |
Trypanosoma cruzi | phytoene synthase, putative | 0.0162 | 0.1475 | 0.2273 |
Echinococcus multilocularis | Squalene phytoene synthase | 0.0162 | 0.1475 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.1475 | 1 |
Treponema pallidum | octaprenyl-diphosphate synthase | 0.0109 | 0 | 0.5 |
Mycobacterium ulcerans | phytoene synthase, CrtB | 0.0465 | 1 | 0.5 |
Onchocerca volvulus | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog | 0.0162 | 0.1475 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 30 uM | Antagonist activity at calcium-sensing receptor expressed in HEK293 cells by FLIPR assay | ChEMBL. | 19143533 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.