Detailed information for compound 976800

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 379.636 | Formula: C16H12BrClN2O2
  • H donors: 2 H acceptors: 2 LogP: 3.93 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1C(=O)N)Br)/C=C/c1cccc(c1)Cl
  • InChi: 1S/C16H12BrClN2O2/c17-11-5-6-14(13(9-11)16(19)22)20-15(21)7-4-10-2-1-3-12(18)8-10/h1-9H,(H2,19,22)(H,20,21)/b7-4+
  • InChiKey: SHRPRXKVHTVRBU-QPJJXVBHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0026 0.0162 0.0411
Giardia lamblia Hypothetical protein 0.0026 0.0162 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0026 0.0162 0.0266
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0026 0.0162 0.0162
Schistosoma mansoni hypothetical protein 0.0188 0.1917 1
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0026 0.0162 0.0162
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0026 0.0162 0.1306
Trichomonas vaginalis superoxide dismutase, putative 0.0077 0.0712 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0026 0.0162 0.0773
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0026 0.0162 0.0773
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0162 0.0411
Trypanosoma brucei iron superoxide dismutase C, mitochondrial 0.0043 0.0352 0.0958
Leishmania major hypothetical protein, conserved 0.0026 0.0162 0.0169
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0162 0.0411
Trypanosoma cruzi iron superoxide dismutase A, mitochondrial 0.0077 0.0712 0.2265
Trypanosoma cruzi iron superoxide dismutase, putative 0.0077 0.0712 0.2265
Schistosoma mansoni ap endonuclease 0.0022 0.0116 0.0603
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Loa Loa (eye worm) hypothetical protein 0.0026 0.0162 0.1306
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0026 0.0162 0.0284
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0125 0.1238 0.1238
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0162 0.0773
Trichomonas vaginalis superoxide dismutase [fe], putative 0.0077 0.0712 1
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0026 0.0162 0.1306
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0162 0.0266
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0116 0.0099
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0026 0.0162 0.0773
Loa Loa (eye worm) hypothetical protein 0.0077 0.0712 0.5753
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0162 0.0773
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Trypanosoma cruzi iron superoxide dismutase, putative 0.0077 0.0712 0.2265
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0125 0.1238 0.1238
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0125 0.1238 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0026 0.0162 0.0162
Trypanosoma cruzi superoxide dismutase, putative 0.0043 0.0352 0.0958
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0162 0.0411
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0026 0.0162 0.0844
Mycobacterium tuberculosis Superoxide dismutase [FE] SodA 0.0077 0.0712 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0162 0.0773
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0026 0.0162 0.0844
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0026 0.0162 0.1306
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0162 0.0773
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0026 0.0162 0.0284
Leishmania major superoxide dismutase, putative 0.0043 0.0352 0.0868
Trypanosoma cruzi iron superoxide dismutase, putative 0.0077 0.0712 0.2265
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0162 0.0411
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0026 0.0162 0.0844
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0026 0.0162 0.0284
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0026 0.0162 0.0284
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Echinococcus granulosus manganese superoxide dismutase 0.0077 0.0712 0.125
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0162 0.0266
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Plasmodium falciparum phosphodiesterase gamma, putative 0.0026 0.0162 0.0773
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.043 0.0755
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0026 0.0162 0.1306
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0026 0.0162 1
Leishmania major superoxide dismutase, putative 0.0043 0.0352 0.0868
Leishmania major iron superoxide dismutase, putative 0.0077 0.0712 0.2188
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0162 0.0411
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.043 0.043
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0162 0.0411
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0125 0.1238 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0026 0.0162 0.0162
Trypanosoma brucei iron superoxide dismutase 0.0077 0.0712 0.2265
Trichomonas vaginalis superoxide dismutase, putative 0.0077 0.0712 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0162 0.0411
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0162 0.0266
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0162 0.0411
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0273 0.2843 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0116 0.0099
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0026 0.0162 0.0773
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0162 0.0411
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0125 0.1238 0.4174
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0162 0.0411
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0026 0.0162 0.0284
Leishmania major iron superoxide dismutase, putative 0.0077 0.0712 0.2188
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0162 0.0773
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0162 0.0266
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0116 0.0934
Trypanosoma cruzi superoxide dismutase, putative 0.0043 0.0352 0.0958
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0162 0.0411
Chlamydia trachomatis superoxide dismutase 0.0077 0.0712 0.5
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0026 0.0162 0.0844
Trypanosoma cruzi iron superoxide dismutase A, mitochondrial 0.0077 0.0712 0.2265
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0162 0.0411
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.043 0.3477
Leishmania major iron superoxide dismutase 0.0077 0.0712 0.2188
Trichomonas vaginalis superoxide dismutase [mn], putative 0.0077 0.0712 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0026 0.0162 0.0844
Plasmodium falciparum superoxide dismutase [Fe] 0.0043 0.0352 0.3969
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0026 0.0162 0.1306
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0162 0.0411
Leishmania major hypothetical protein, conserved 0.0026 0.0162 0.0169
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0162 0.0773
Trypanosoma cruzi superoxide dismutase, putative 0.0043 0.0352 0.0958
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.043 0.3477
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0162 0.0411
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0125 0.1238 0.4174
Mycobacterium ulcerans superoxide dismutase [Fe] SodA 0.0077 0.0712 1
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0162 0.0266
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog 0.0077 0.0712 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0125 0.1238 0.2172
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.043 0.0755
Echinococcus multilocularis neuropeptide s receptor 0.0537 0.5701 0.5701
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0162 0.0266
Plasmodium falciparum superoxide dismutase [Fe] 0.0077 0.0712 1
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0125 0.1238 0.646
Plasmodium vivax superoxide dismutase [Fe], putative 0.0077 0.0712 0.5316
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0116 0.0203
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0125 0.1238 0.4174
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0026 0.0162 0.1306
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.043 0.2246
Schistosoma mansoni superoxide dismutase [mn] 0.0077 0.0712 0.3717
Leishmania major cAMP-specific phosphodiesterase, putative 0.0273 0.2843 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0026 0.0162 0.0284
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0162 0.0773
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0026 0.0162 0.0266
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.043 0.043
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0162 0.0773
Wolbachia endosymbiont of Brugia malayi superoxide dismutase, SodA 0.0077 0.0712 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0116 0.5
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog 0.0077 0.0712 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.043 0.2246
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0026 0.0162 0.0773
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Plasmodium vivax superoxide dismutase [Fe], putative 0.0043 0.0352 0.211
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.043 0.2246
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0026 0.0162 0.0773
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0026 0.0162 0.0844
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0026 0.0162 0.0773
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Toxoplasma gondii superoxide dismutase SOD3 0.0077 0.0712 0.5316
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0026 0.0162 0.0773
Mycobacterium leprae Probable superoxide dismutase SodA 0.0077 0.0712 0.5
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0026 0.0162 0.0844
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0026 0.0162 0.0773
Toxoplasma gondii superoxide dismutase 0.0077 0.0712 0.5316
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0162 0.0411
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0026 0.0162 0.0773
Trypanosoma brucei superoxide dismutase, putative 0.0043 0.0352 0.0958
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Loa Loa (eye worm) hypothetical protein 0.0026 0.0162 0.1306
Trichomonas vaginalis iron superoxide dismutase A, putative 0.0077 0.0712 1
Trichomonas vaginalis superoxide dismutase [fe], putative 0.0077 0.0712 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0273 0.2843 1
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog 0.0052 0.0448 0.6295
Loa Loa (eye worm) hypothetical protein 0.0026 0.0162 0.1306
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0162 0.0773
Loa Loa (eye worm) hypothetical protein 0.0026 0.0162 0.1306
Brugia malayi Superoxide dismutase, mitochondrial precursor, putative 0.0077 0.0712 0.5753
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0026 0.0162 0.0266
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0026 0.0162 0.0266
Trypanosoma brucei iron superoxide dismutase A, mitochondrial 0.0077 0.0712 0.2265
Trichomonas vaginalis superoxide dismutase [fe], putative 0.0077 0.0712 1
Entamoeba histolytica iron-containing superoxide dismutase 0.0077 0.0712 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0162 0.0773
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0125 0.1238 0.2172
Echinococcus granulosus neuropeptide s receptor 0.0537 0.5701 1
Trypanosoma cruzi iron superoxide dismutase, putative 0.0052 0.0448 0.1307
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0026 0.0162 0.0266
Echinococcus multilocularis neuropeptide receptor A26 0.0537 0.5701 0.5701
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0116 0.0116
Echinococcus granulosus neuropeptide receptor A26 0.0537 0.5701 1
Schistosoma mansoni hypothetical protein 0.0188 0.1917 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0162 0.0411
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0116 0.0099
Echinococcus multilocularis geminin 0.0188 0.1917 0.1917
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0162 0.0773
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0026 0.0162 0.0162
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0125 0.1238 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0026 0.0162 0.0266
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0026 0.0162 0.0844
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0125 0.1238 0.4117
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0162 0.0266
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0026 0.0162 0.0266
Trypanosoma brucei iron superoxide dismutase 0.0077 0.0712 0.2265
Schistosoma mansoni ap endonuclease 0.0022 0.0116 0.0603
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0026 0.0162 0.0844
Plasmodium vivax phosphodiesterase gamma, putative 0.0026 0.0162 0.0411
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0026 0.0162 0.0162
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0162 0.0411
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0116 0.0934
Giardia lamblia hypothetical protein 0.0026 0.0162 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0162 0.0773
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0162 0.0266
Loa Loa (eye worm) PDE1B protein 0.0125 0.1238 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0162 0.0773
Plasmodium falciparum phosphodiesterase delta, putative 0.0026 0.0162 0.0773
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0026 0.0162 0.0773
Echinococcus multilocularis manganese superoxide dismutase 0.0077 0.0712 0.0712
Trypanosoma cruzi superoxide dismutase, putative 0.0043 0.0352 0.0958
Toxoplasma gondii superoxide dismutase SOD2 0.0077 0.0712 0.5316
Echinococcus granulosus geminin 0.0188 0.1917 0.3362
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0026 0.0162 0.0844
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0162 0.0773
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0125 0.1238 1
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0162 0.0266

Activities

Activity type Activity value Assay description Source Reference
GI (functional) = 25.5 % Antiproliferative activity against human K562 cells at 10 uM after 48 hrs by trypan blue assay ChEMBL. 21530013
IC50 (functional) > 10 uM Growth inhibition of human K562 cells after 48 hrs by trypan blue assay ChEMBL. 21530013

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 21530013

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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