TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 423.302 | Formula: C22H19BrN2O2
H donors: 2 H acceptors: 2 LogP: 5.5 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCCCc1cccc2c1[nH]c(c2C1=C(Br)C(=O)NC1=O)c1ccccc1
InChi: 1S/C22H19BrN2O2/c1-2-3-8-13-11-7-12-15-16(17-18(23)22(27)25-21(17)26)20(24-19(13)15)14-9-5-4-6-10-14/h4-7,9-12,24H,2-3,8H2,1H3,(H,25,26,27)
InChiKey: JTUSPUPWPULRBP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0028	0.174	0.1569
Echinococcus multilocularis	neuropeptide receptor A26	0.0028	0.174	0.1569
Echinococcus multilocularis	neuropeptide Y receptor	0.0028	0.174	0.1569
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0028	0.174	0.1621
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0028	0.174	0.1569
Brugia malayi	Dopamine receptor protein 2	0.0028	0.174	0.1569
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.174	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Echinococcus multilocularis	voltage dependent calcium channel	0.0051	0.4365	0.4249
Echinococcus granulosus	G protein coupled receptor 139	0.0028	0.174	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Echinococcus granulosus	g protein coupled receptor	0.0028	0.174	0.1569
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.174	0.1569
Brugia malayi	GnHR receptor homolog	0.0028	0.174	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.174	0.1569
Echinococcus multilocularis	G protein coupled receptor 139	0.0028	0.174	0.1569
Echinococcus granulosus	neuropeptide Y receptor	0.0028	0.174	0.1569
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0028	0.174	0.1569
Echinococcus multilocularis	serotonin receptor	0.0028	0.174	0.1569
Brugia malayi	G protein-coupled receptor	0.0028	0.174	0.1569
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.174	0.2215
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.174	0.1569
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.174	0.2215
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Echinococcus multilocularis	fmrfamide receptor	0.0028	0.174	0.1569
Echinococcus multilocularis	neuropeptide s receptor	0.0028	0.174	0.1569
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.005	0.4238	0.412
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Echinococcus multilocularis	allatostatin A receptor	0.0028	0.174	0.1569
Echinococcus granulosus	g-protein coupled receptor	0.0028	0.174	0.1569
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.174	0.1569
Schistosoma mansoni	hypothetical protein	0.0028	0.174	0.2215
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.174	0.1569
Schistosoma mansoni	voltage-gated potassium channel	0.0019	0.0664	0.0846
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0051	0.4365	0.4249
Brugia malayi	putative neuropeptide receptor	0.0028	0.174	0.1569
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0028	0.174	0.1569
Echinococcus granulosus	voltage dependent calcium channel	0.0051	0.4365	0.4249
Schistosoma mansoni	hypothetical protein	0.0082	0.7854	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0028	0.174	0.1569
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.174	0.1569
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0028	0.174	0.1569
Schistosoma mansoni	biogenic amine receptor	0.0028	0.174	0.2215
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0051	0.4365	0.5
Echinococcus granulosus	neuropeptide receptor	0.0028	0.174	0.1569
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.174	0.1569
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.174	0.2215
Echinococcus multilocularis	somatostatin receptor	0.0028	0.174	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.174	0.1569
Schistosoma mansoni	amine GPCR	0.0028	0.174	0.2215
Loa Loa (eye worm)	hypothetical protein	0.0042	0.3372	0.3342
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0015	0.0202	0.0258
Echinococcus multilocularis	neuropeptide receptor	0.0028	0.174	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Loa Loa (eye worm)	neuropeptide F receptor	0.0028	0.174	0.1621
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.174	0.1569
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0028	0.174	0.1621
Brugia malayi	hypothetical protein	0.0028	0.174	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0051	0.4365	0.4249
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Brugia malayi	putative neuropeptide receptor NPR1	0.0028	0.174	0.1569
Schistosoma mansoni	histamine h1 receptor	0.0028	0.174	0.2215
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0664	0.0487
Loa Loa (eye worm)	G-protein coupled receptor	0.0028	0.174	0.1621
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Loa Loa (eye worm)	hypothetical protein	0.0042	0.3372	0.3342
Echinococcus multilocularis	fmrfamide receptor	0.0028	0.174	0.1569
Brugia malayi	larval opioid receptor	0.0028	0.174	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0051	0.4365	0.439
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0041	0.3245	1
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0015	0.0202	0.0258
Schistosoma mansoni	jun-related protein	0.0082	0.7854	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.174	0.1569
Echinococcus granulosus	somatostatin receptor	0.0028	0.174	0.1569
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0028	0.174	0.1569
Loa Loa (eye worm)	G-protein coupled receptor	0.0028	0.174	0.1621
Loa Loa (eye worm)	melatonin receptor type 1A	0.0028	0.174	0.1621
Echinococcus granulosus	neuropeptide Y receptor	0.0028	0.174	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Echinococcus granulosus	fmrfamide receptor	0.0028	0.174	0.1569
Echinococcus granulosus	orexin receptor type 2	0.0028	0.174	0.1569
Echinococcus multilocularis	serotonin receptor	0.0028	0.174	0.1569
Echinococcus granulosus	voltage gated potassium channel	0.0019	0.0664	0.0472
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.005	0.4238	0.412
Schistosoma mansoni	hypothetical protein	0.0028	0.174	0.2215
Echinococcus granulosus	g protein coupled receptor	0.0028	0.174	0.1569
Echinococcus multilocularis	voltage dependent calcium channel	0.0051	0.4365	0.4249
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0028	0.174	0.2215
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0028	0.174	0.1569
Brugia malayi	hypothetical protein	0.0028	0.174	0.1569
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.005	0.4238	0.4256
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Loa Loa (eye worm)	hypothetical protein	0.0098	0.9686	1
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.174	0.1569
Echinococcus granulosus	neuropeptide s receptor	0.0028	0.174	0.1569
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.174	0.2215
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0051	0.4365	0.4249
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.005	0.4238	0.412
Toxoplasma gondii	transporter, cation channel family protein	0.0051	0.4365	1
Echinococcus multilocularis	jun protein	0.0101	1	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Echinococcus granulosus	jun protein	0.0101	1	1
Brugia malayi	hypothetical protein	0.0079	0.754	0.7489
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0028	0.174	0.1569
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0101	1	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0028	0.174	0.2215
Brugia malayi	Dopamine receptor protein 1	0.0028	0.174	0.1569
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.174	0.2215
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.174	0.1569
Onchocerca volvulus		0.0079	0.754	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0028	0.174	0.1569
Echinococcus granulosus	allatostatin A receptor	0.0028	0.174	0.1569
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0051	0.4365	0.4249
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.174	0.2215
Echinococcus granulosus	biogenic amine 5HT receptor	0.0028	0.174	0.1569
Echinococcus granulosus	7tm_1 domain containing protein	0.0028	0.174	0.1569
Brugia malayi	neuropeptide F receptor	0.0028	0.174	0.1569
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0028	0.174	0.2215
Brugia malayi	G-protein coupled receptor	0.0028	0.174	0.1569
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0028	0.174	0.2215
Echinococcus multilocularis	voltage gated potassium channel	0.0019	0.0664	0.0472
Schistosoma mansoni	opsin-like receptor	0.0028	0.174	0.2215
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.174	0.1569
Schistosoma mansoni	neuropeptide receptor	0.0028	0.174	0.2215
Brugia malayi	sulfakinin receptor protein	0.0028	0.174	0.1569
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0015	0.0202	0.0258
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0028	0.174	0.1569
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.174	0.2215
Schistosoma mansoni	opsin-like receptor	0.0028	0.174	0.2215
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.174	0.1569
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0051	0.4365	0.4249
Schistosoma mansoni	amine GPCR	0.0028	0.174	0.2215
Echinococcus granulosus	neuropeptides capa receptor	0.0028	0.174	0.1569
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.174	0.1569
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0028	0.174	0.2215
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.174	0.2215
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Schistosoma mansoni	voltage-gated potassium channel	0.0054	0.4701	0.5985
Echinococcus granulosus	g protein coupled receptor	0.0028	0.174	0.1569
Echinococcus granulosus	neuropeptide FF receptor 2	0.0028	0.174	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0044	0.3574	0.3555
Echinococcus multilocularis	orexin receptor type 2	0.0028	0.174	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.174	0.2215
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.174	0.1569
Echinococcus multilocularis	sex peptide receptor	0.0028	0.174	0.1569
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.174	0.2215
Brugia malayi	AKH receptor	0.0028	0.174	0.1569
Schistosoma mansoni	biogenic amine receptor	0.0028	0.174	0.2215
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0051	0.4365	0.4249
Brugia malayi	Serotonin receptor	0.0028	0.174	0.1569
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0041	0.3245	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0028	0.174	0.1569
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0051	0.4365	0.4249
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0051	0.4365	0.4249
Loa Loa (eye worm)	hypothetical protein	0.0051	0.4365	0.439
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.174	0.1569
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0028	0.174	0.1569
Brugia malayi	hypothetical protein	0.0028	0.174	0.1569
Schistosoma mansoni	hypothetical protein	0.0028	0.174	0.2215
Loa Loa (eye worm)	calcium channel	0.0051	0.4365	0.439
Echinococcus granulosus	neuropeptide receptor A26	0.0028	0.174	0.1569
Schistosoma mansoni	neuropeptide receptor	0.0028	0.174	0.2215
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0028	0.174	0.1569
Brugia malayi	follicle stimulating hormone receptor	0.0028	0.174	0.1569
Echinococcus granulosus	biogenic amine 5HT receptor	0.0028	0.174	0.1569
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0028	0.174	0.1569
Schistosoma mansoni	myosin xvIII	0.0028	0.174	0.2215
Schistosoma mansoni	neuropeptide F-like receptor	0.0028	0.174	0.2215
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0015	0.0202	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0028	0.174	0.2215
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0028	0.174	0.2215
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.174	0.2215
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0028	0.174	0.1569
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0028	0.174	0.1569
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.174	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Echinococcus granulosus	hypothetical protein	0.0028	0.174	0.1569
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0028	0.174	0.1569
Schistosoma mansoni	neuropeptide receptor	0.0028	0.174	0.2215
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0028	0.174	0.1621
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.174	0.1569
Loa Loa (eye worm)	neuropeptide F receptor	0.0028	0.174	0.1621
Echinococcus multilocularis	neuropeptide Y receptor	0.0028	0.174	0.1569
Brugia malayi	G protein-coupled receptor F59B2.13	0.0028	0.174	0.1569
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0051	0.4365	0.5
Schistosoma mansoni	amine GPCR	0.0028	0.174	0.2215
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.174	0.1569
Echinococcus granulosus	7TM GPCR rhodopsin	0.0028	0.174	0.1569
Schistosoma mansoni	hypothetical protein	0.0028	0.174	0.2215
Echinococcus multilocularis	neuropeptides capa receptor	0.0028	0.174	0.1569
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0028	0.174	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Brugia malayi	hypothetical protein	0.0028	0.174	0.1569
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0028	0.174	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0028	0.174	0.1621
Brugia malayi	hypothetical protein	0.0028	0.174	0.1569
Brugia malayi	hypothetical protein	0.0028	0.174	0.1569
Brugia malayi	RE15519p	0.0028	0.174	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0028	0.174	0.1569
Schistosoma mansoni	opsin-like receptor	0.0028	0.174	0.2215
Echinococcus granulosus	neuropeptide receptor	0.0028	0.174	0.1569
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0019	0.0664	0.0472
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0028	0.174	0.1569
Schistosoma mansoni	voltage-gated cation channel	0.0051	0.4365	0.5558
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.174	0.2215
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0101	1	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0028	0.174	0.2215
Schistosoma mansoni	amine GPCR	0.0028	0.174	0.2215
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0028	0.174	0.1569
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0051	0.4365	0.5558
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Schistosoma mansoni	biogenic amine receptor	0.0028	0.174	0.2215
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0019	0.0664	0.0472
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0028	0.174	0.2215
Schistosoma mansoni	voltage-gated potassium channel	0.0019	0.0664	0.0846
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Brugia malayi	hypothetical protein	0.0028	0.174	0.1569
Echinococcus granulosus	serotonin receptor	0.0028	0.174	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Echinococcus granulosus	sex peptide receptor	0.0028	0.174	0.1569
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0028	0.174	0.1569
Schistosoma mansoni	neuropeptide receptor	0.0028	0.174	0.2215
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0028	0.174	0.1569
Brugia malayi	ORL1-like opioid receptor	0.0028	0.174	0.1569
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0019	0.0664	0.0472
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0028	0.174	0.1621
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0028	0.174	0.1569
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.174	0.1569
Echinococcus multilocularis	g-protein coupled receptor	0.0028	0.174	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Brugia malayi	hypothetical protein	0.0028	0.174	0.1569
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.174	0.1569
Brugia malayi	Melatonin receptor type 1A	0.0028	0.174	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Echinococcus multilocularis	neuropeptide receptor	0.0028	0.174	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Loa Loa (eye worm)	TYRA-2 protein	0.0028	0.174	0.1621
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0028	0.174	0.2215
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0028	0.174	0.1569
Echinococcus granulosus	neuropeptides capa receptor	0.0028	0.174	0.1569
Brugia malayi	Dopamine receptor	0.0028	0.174	0.1569
Brugia malayi	Serotonin receptor	0.0028	0.174	0.1569
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0015	0.0202	0.0258
Echinococcus multilocularis	neuropeptides capa receptor	0.0028	0.174	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Echinococcus multilocularis	dro:myosuppressin receptor	0.0028	0.174	0.1569
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0028	0.174	0.2215
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0028	0.174	0.2215
Schistosoma mansoni	adenoreceptor	0.0028	0.174	0.2215
Schistosoma mansoni	voltage-gated potassium channel	0.0015	0.0202	0.0258
Schistosoma mansoni	growth hormone secretagogue receptor	0.0028	0.174	0.2215
Schistosoma mansoni	neuropeptide F-like receptor	0.0028	0.174	0.2215
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Brugia malayi	hypothetical protein	0.0028	0.174	0.1569
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0051	0.4365	0.439
Brugia malayi	hypothetical protein	0.0028	0.174	0.1569
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0028	0.174	0.2215
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.174	0.1569
Brugia malayi	neuropeptide F receptor	0.0028	0.174	0.1569
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0028	0.174	0.1569
Schistosoma mansoni	neuropeptide f receptor 76f	0.0028	0.174	0.2215
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0051	0.4365	0.5558
Schistosoma mansoni	amine GPCR	0.0028	0.174	0.2215
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Brugia malayi	G-protein coupled receptor	0.0028	0.174	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0028	0.174	0.1621
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0028	0.174	0.1569
Schistosoma mansoni	voltage-gated potassium channel	0.0054	0.4701	0.5985
Echinococcus granulosus	voltage dependent calcium channel	0.0051	0.4365	0.4249

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)		Antibacterial activity against Candida albicans after 24 hrs by broth microdilution method	ChEMBL.	17624634
Activity (functional)		Antibacterial activity against Escherichia coli after 24 hrs by broth microdilution method	ChEMBL.	17624634

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL476898

Bibliographic References

No literature references available for this target.

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Detailed information for compound 977808