Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0083 | 0.2653 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0206 | 0.8618 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0347 | 0.5 |
Brugia malayi | bZIP transcription factor family protein | 0.0083 | 0.2653 | 0.3036 |
Echinococcus granulosus | jun protein | 0.0083 | 0.2653 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0347 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0347 | 0.1596 |
Brugia malayi | hypothetical protein | 0.0065 | 0.1787 | 0.2025 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.1898 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0347 | 0.1132 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.2543 | 0.2907 |
Schistosoma mansoni | jun-related protein | 0.0068 | 0.1898 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0053 | 0.5 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0347 | 0.0344 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0347 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0347 | 0.1596 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0083 | 0.2653 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0053 | 0.0199 |
Echinococcus multilocularis | jun protein | 0.0083 | 0.2653 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0206 | 0.8618 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0053 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0347 | 0.1308 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0347 | 0.5 |
Onchocerca volvulus | 0.0065 | 0.1787 | 0.1743 | |
Trichomonas vaginalis | set domain proteins, putative | 0.0234 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.