Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | amino acid permease | 0.0253 | 1 | 1 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.007 | 0.1183 | 0.1183 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.007 | 0.1183 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.8267 | 0.8267 |
Trypanosoma cruzi | aminopeptidase, putative | 0.007 | 0.1183 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.007 | 0.1183 | 0.1183 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Echinococcus granulosus | solute carrier family 12 | 0.0253 | 1 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.007 | 0.1183 | 0.5 |
Onchocerca volvulus | 0.007 | 0.1183 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.8267 | 0.8267 |
Schistosoma mansoni | solute carrier family 12 electroneutral k-cl cotransporter | 0.0253 | 1 | 1 |
Onchocerca volvulus | 0.007 | 0.1183 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.8267 | 0.8267 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.007 | 0.1183 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.007 | 0.1183 | 0.1183 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.8267 | 0.8267 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.007 | 0.1183 | 0.1183 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.8267 | 0.8267 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.007 | 0.1183 | 0.5 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.007 | 0.1183 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.007 | 0.1183 | 0.1183 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.007 | 0.1183 | 0.1183 |
Loa Loa (eye worm) | aminopeptidase N | 0.007 | 0.1183 | 0.1183 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.007 | 0.1183 | 0.1183 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.007 | 0.1183 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.007 | 0.1183 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.8267 | 0.8267 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.007 | 0.1183 | 0.1183 |
Echinococcus multilocularis | solute carrier family 12 | 0.0253 | 1 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.007 | 0.1183 | 0.1183 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.007 | 0.1183 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.007 | 0.1183 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.8267 | 0.8267 |
Brugia malayi | Amino acid permease family protein | 0.0253 | 1 | 1 |
Entamoeba histolytica | aminopeptidase, putative | 0.007 | 0.1183 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.007 | 0.1183 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 2.1 ug ml-1 | Cytotoxicity against human KB cells | ChEMBL. | 8277314 |
ED50 (functional) | = 3.9 ug ml-1 | Cytotoxicity against mouse P388 cells | ChEMBL. | 8277314 |
ED50 (functional) | = 9.3 ug ml-1 | Cytotoxicity against mouse doxorubicin-resistant P388 cells | ChEMBL. | 8277314 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.