Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | casein kinase II, putative | 0.0156 | 0.6928 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0156 | 0.6928 | 1 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0156 | 0.6928 | 1 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0156 | 0.6928 | 0.6928 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0156 | 0.6928 | 0.6928 |
Onchocerca volvulus | 0.0058 | 0 | 0.5 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0199 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0156 | 0.6928 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0199 | 1 | 1 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0156 | 0.6928 | 0.6928 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0156 | 0.6928 | 1 |
Echinococcus granulosus | homeodomain interacting protein kinase 3 | 0.0199 | 1 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/HIPK protein kinase | 0.0199 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0156 | 0.6928 | 1 |
Schistosoma mansoni | protein kinase | 0.0156 | 0.6928 | 0.6928 |
Leishmania major | casein kinase II, putative | 0.0156 | 0.6928 | 1 |
Brugia malayi | Casein kinase II, alpha chain | 0.0156 | 0.6928 | 0.6928 |
Echinococcus multilocularis | homeodomain interacting protein kinase 3 | 0.0199 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0156 | 0.6928 | 1 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0156 | 0.6928 | 1 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0156 | 0.6928 | 1 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0156 | 0.6928 | 1 |
Entamoeba histolytica | casein kinase, putative | 0.0156 | 0.6928 | 0.6928 |
Trypanosoma brucei | Casein kinase II | 0.0156 | 0.6928 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0156 | 0.6928 | 0.6928 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0156 | 0.6928 | 1 |
Plasmodium vivax | unspecified product | 0.0156 | 0.6928 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0156 | 0.6928 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 500 ug ml-1 | Antibacterial activity against Escherichia coli after 24 hrs by NCCLS microdilution method | ChEMBL. | 19195884 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.