Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphorylase, glycogen, liver | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 2, subfamily C, polypeptide 9 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | cytochrome P450, family 2, subfamily C, polypeptide 9 | 490 aa | 441 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0172 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0172 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0172 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0172 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0172 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0172 | 1 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.013 | 0.7129 | 0.7129 |
Brugia malayi | Animal haem peroxidase family protein | 0.0172 | 1 | 1 |
Onchocerca volvulus | 0.0172 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 1 | 1 |
Onchocerca volvulus | 0.0172 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0172 | 1 | 1 |
Brugia malayi | carbohydrate phosphorylase | 0.013 | 0.7129 | 0.7129 |
Schistosoma mansoni | peroxidasin | 0.0172 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.013 | 0.7129 | 0.6407 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0172 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.013 | 0.7129 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 1 | 1 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0056 | 0.201 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0172 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.013 | 0.7129 | 1 |
Onchocerca volvulus | 0.0172 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0172 | 1 | 1 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0056 | 0.201 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.013 | 0.7129 | 0.6407 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.013 | 0.7129 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0172 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 1 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.013 | 0.7129 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0172 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0172 | 1 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.013 | 0.7129 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.013 | 0.7129 | 1 |
Brugia malayi | Peroxidasin | 0.0172 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0172 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0172 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0172 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0172 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0172 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0172 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 97 nM | Inhibition of human liver glycogen phosphorylase A by fluorescence intensity endpoint assay in presence of glucose | ChEMBL. | 19095442 |
IC50 (ADMET) | = 2400 nM | Inhibition of CYP2C9 | ChEMBL. | 19095442 |
IC50 (binding) | = 4873 nM | Inhibition of human liver glycogen phosphorylase A in HepG2 cells assessed as forskolin-induced glycogenolysis | ChEMBL. | 19095442 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.