Detailed information for compound 984204
Basic information
Technical information
Network
Hover on a compound node to display the structore
Synonyms
No synonyms found for this compound
Targets
Known targets for this compound
| Species | Target name | Source | Bibliographic reference |
|---|---|---|---|
| Rattus norvegicus | Nitric-oxide synthase, brain | Starlite/ChEMBL | References |
Predicted pathogen targets for this compound
By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0035 | 1 | 1 |
| Onchocerca volvulus | 0.0035 | 1 | 0.5 | |
| Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0035 | 1 | 1 |
| Brugia malayi | G protein-coupled receptor | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Brugia malayi | sulfakinin receptor protein | 0.0035 | 1 | 1 |
| Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0027 | 0.6294 | 1 |
| Onchocerca volvulus | 0.0035 | 1 | 0.5 | |
| Echinococcus granulosus | g protein coupled receptor | 0.0035 | 1 | 1 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.6294 | 0.5669 |
| Schistosoma mansoni | hypothetical protein | 0.0035 | 1 | 1 |
| Schistosoma mansoni | neuropeptide F-like receptor | 0.0035 | 1 | 1 |
| Brugia malayi | AKH receptor | 0.0035 | 1 | 1 |
| Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0035 | 1 | 1 |
| Onchocerca volvulus | 0.0035 | 1 | 0.5 | |
| Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Echinococcus granulosus | 7TM GPCR rhodopsin | 0.0035 | 1 | 1 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.0035 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0035 | 1 | 1 |
| Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0017 | 0.1442 | 0.1442 |
| Schistosoma mansoni | biogenic amine receptor | 0.0035 | 1 | 1 |
| Echinococcus granulosus | tachykinin peptides receptor 99D | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | g protein coupled receptor | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | somatostatin receptor | 0.0035 | 1 | 1 |
| Trichomonas vaginalis | sulfite reductase, putative | 0.0027 | 0.6294 | 1 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.0035 | 1 | 1 |
| Onchocerca volvulus | 0.0035 | 1 | 0.5 | |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Echinococcus granulosus | G protein coupled receptor 139 | 0.0035 | 1 | 1 |
| Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | fmrfamide receptor | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Schistosoma mansoni | neuropeptide receptor | 0.0035 | 1 | 1 |
| Brugia malayi | flavodoxin family protein | 0.0027 | 0.6294 | 0.5669 |
| Loa Loa (eye worm) | neuropeptide F receptor | 0.0035 | 1 | 1 |
| Brugia malayi | larval opioid receptor | 0.0035 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0035 | 1 | 1 |
| Schistosoma mansoni | amine GPCR | 0.0035 | 1 | 1 |
| Schistosoma mansoni | myosin xvIII | 0.0035 | 1 | 1 |
| Echinococcus granulosus | biogenic amine 5HT receptor | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | neuropeptide receptor | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Brugia malayi | Dopamine receptor protein 2 | 0.0035 | 1 | 1 |
| Schistosoma mansoni | amine GPCR | 0.0035 | 1 | 1 |
| Brugia malayi | neuropeptide F receptor | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Onchocerca volvulus | 0.0035 | 1 | 0.5 | |
| Onchocerca volvulus | 0.0035 | 1 | 0.5 | |
| Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0027 | 0.6294 | 0.5 |
| Schistosoma mansoni | hypothetical protein | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | G-protein coupled receptor, putative | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0035 | 1 | 1 |
| Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0035 | 1 | 1 |
| Onchocerca volvulus | 0.0035 | 1 | 0.5 | |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0035 | 1 | 1 |
| Schistosoma mansoni | cytochrome P450 reductase | 0.0027 | 0.6294 | 0.6294 |
| Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0035 | 1 | 1 |
| Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0035 | 1 | 1 |
| Echinococcus granulosus | growth hormone secretagogue receptor type 1 | 0.0035 | 1 | 1 |
| Plasmodium falciparum | nitric oxide synthase, putative | 0.0027 | 0.6294 | 0.5 |
| Schistosoma mansoni | neuropeptide receptor | 0.0035 | 1 | 1 |
| Echinococcus granulosus | thyrotropin releasing hormone receptor | 0.0035 | 1 | 1 |
| Brugia malayi | G-protein coupled receptor | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | serotonin receptor | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | neuropeptide receptor | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0035 | 1 | 1 |
| Schistosoma mansoni | histamine h1 receptor | 0.0035 | 1 | 1 |
| Echinococcus granulosus | g protein coupled receptor | 0.0035 | 1 | 1 |
| Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0027 | 0.6294 | 0.5669 |
| Trypanosoma cruzi | p450 reductase, putative | 0.0027 | 0.6294 | 0.5 |
| Brugia malayi | hypothetical protein | 0.0035 | 1 | 1 |
| Schistosoma mansoni | adenoreceptor | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | neuropeptides capa receptor | 0.0035 | 1 | 1 |
| Schistosoma mansoni | hypothetical protein | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0027 | 0.6294 | 0.5 |
| Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0035 | 1 | 1 |
| Echinococcus granulosus | tm gpcr rhodopsin | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | G-protein coupled receptor | 0.0035 | 1 | 1 |
| Echinococcus granulosus | neuropeptide receptor A26 | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Onchocerca volvulus | 0.0035 | 1 | 0.5 | |
| Echinococcus multilocularis | neuropeptide s receptor | 0.0035 | 1 | 1 |
| Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0027 | 0.6294 | 0.5669 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0035 | 1 | 1 |
| Echinococcus granulosus | neuropeptide receptor | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Onchocerca volvulus | 0.0035 | 1 | 0.5 | |
| Schistosoma mansoni | growth hormone secretagogue receptor | 0.0035 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0035 | 1 | 1 |
| Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0027 | 0.6294 | 1 |
| Brugia malayi | GnHR receptor homolog | 0.0035 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0035 | 1 | 1 |
| Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | dro:myosuppressin receptor | 0.0035 | 1 | 1 |
| Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0035 | 1 | 1 |
| Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0035 | 1 | 1 |
| Brugia malayi | RE15519p | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | sex peptide receptor | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0035 | 1 | 1 |
| Echinococcus granulosus | G protein coupled 5 hydroxytryptamine receptor | 0.0035 | 1 | 1 |
| Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0035 | 1 | 1 |
| Brugia malayi | Serotonin receptor | 0.0035 | 1 | 1 |
| Brugia malayi | neuropeptide F receptor | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0035 | 1 | 1 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Echinococcus granulosus | biogenic amine 5HT receptor | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Echinococcus granulosus | neuropeptide Y receptor | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | orexin receptor type 2 | 0.0035 | 1 | 1 |
| Onchocerca volvulus | 0.0035 | 1 | 0.5 | |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Brugia malayi | putative neuropeptide receptor | 0.0035 | 1 | 1 |
| Brugia malayi | G-protein coupled receptor | 0.0035 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0035 | 1 | 1 |
| Giardia lamblia | Nitric oxide synthase, inducible | 0.0024 | 0.4852 | 0.5 |
| Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0035 | 1 | 1 |
| Brugia malayi | Serotonin receptor | 0.0035 | 1 | 1 |
| Schistosoma mansoni | amine GPCR | 0.0035 | 1 | 1 |
| Schistosoma mansoni | amine GPCR | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | g protein coupled receptor | 0.0035 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0035 | 1 | 1 |
| Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0027 | 0.6294 | 0.5 |
| Onchocerca volvulus | 0.0035 | 1 | 0.5 | |
| Schistosoma mansoni | neuropeptide f receptor 76f | 0.0035 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0035 | 1 | 1 |
| Brugia malayi | FAD binding domain containing protein | 0.0027 | 0.6294 | 0.5669 |
| Echinococcus granulosus | dro:myosuppressin receptor | 0.0035 | 1 | 1 |
| Echinococcus granulosus | orexin receptor type 2 | 0.0035 | 1 | 1 |
| Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0035 | 1 | 1 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | peptide (allatostatin:somatostatin) | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | 0.0035 | 1 | 1 |
| Echinococcus granulosus | neuropeptide FF receptor 2 | 0.0035 | 1 | 1 |
| Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0027 | 0.6294 | 0.5 |
| Echinococcus multilocularis | allatostatin A receptor | 0.0035 | 1 | 1 |
| Echinococcus granulosus | neuropeptide Y receptor | 0.0035 | 1 | 1 |
| Echinococcus granulosus | neuropeptide receptor | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | alpha 1A adrenergic receptor | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | neuropeptides capa receptor | 0.0035 | 1 | 1 |
| Echinococcus granulosus | allatostatin A receptor | 0.0035 | 1 | 1 |
| Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0035 | 1 | 1 |
| Onchocerca volvulus | 0.0035 | 1 | 0.5 | |
| Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.0035 | 1 | 1 |
| Schistosoma mansoni | opsin-like receptor | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0035 | 1 | 1 |
| Echinococcus granulosus | somatostatin receptor | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0027 | 0.6294 | 0.5669 |
| Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0027 | 0.6294 | 0.5669 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Brugia malayi | ORL1-like opioid receptor | 0.0035 | 1 | 1 |
| Onchocerca volvulus | 0.0035 | 1 | 0.5 | |
| Echinococcus granulosus | fmrfamide receptor | 0.0035 | 1 | 1 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0035 | 1 | 1 |
| Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0027 | 0.6294 | 0.5 |
| Echinococcus granulosus | alpha 1A adrenergic receptor | 0.0035 | 1 | 1 |
| Onchocerca volvulus | 0.0035 | 1 | 0.5 | |
| Echinococcus multilocularis | neuropeptide receptor A26 | 0.0035 | 1 | 1 |
| Echinococcus granulosus | hypothetical protein | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0027 | 0.6294 | 0.5669 |
| Echinococcus granulosus | 7tm_1 domain containing protein | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | neuropeptide Y receptor | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0035 | 1 | 1 |
| Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | neuropeptide FF receptor 2 | 0.0035 | 1 | 1 |
| Schistosoma mansoni | amine GPCR | 0.0035 | 1 | 1 |
| Echinococcus granulosus | neuropeptide s receptor | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Brugia malayi | Dopamine receptor protein 1 | 0.0035 | 1 | 1 |
| Echinococcus granulosus | serotonin receptor | 0.0035 | 1 | 1 |
| Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0027 | 0.6294 | 0.5 |
| Schistosoma mansoni | biogenic amine receptor | 0.0035 | 1 | 1 |
| Schistosoma mansoni | neuropeptide F-like receptor | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | neuropeptide Y receptor | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | G protein coupled 5 hydroxytryptamine receptor | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | 0.0035 | 1 | 1 |
| Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0035 | 1 | 0.5 |
| Loa Loa (eye worm) | TYRA-2 protein | 0.0035 | 1 | 1 |
| Brugia malayi | putative neuropeptide receptor NPR1 | 0.0035 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0035 | 1 | 1 |
| Echinococcus granulosus | neuropeptides capa receptor | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0035 | 1 | 1 |
| Schistosoma mansoni | opsin-like receptor | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | neuropeptide F receptor | 0.0035 | 1 | 1 |
| Echinococcus granulosus | peptide allatostatin:somatostatin | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0035 | 1 | 1 |
| Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0035 | 1 | 1 |
| Brugia malayi | Dopamine receptor | 0.0035 | 1 | 1 |
| Brugia malayi | follicle stimulating hormone receptor | 0.0035 | 1 | 1 |
| Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0035 | 1 | 1 |
| Schistosoma mansoni | neuropeptide receptor | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0035 | 1 | 1 |
| Chlamydia trachomatis | sulfite reductase | 0.0017 | 0.1442 | 0.5 |
| Onchocerca volvulus | 0.0035 | 1 | 0.5 | |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Echinococcus granulosus | sex peptide receptor | 0.0035 | 1 | 1 |
| Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | G protein coupled receptor 139 | 0.0035 | 1 | 1 |
| Schistosoma mansoni | biogenic amine receptor | 0.0035 | 1 | 1 |
| Schistosoma mansoni | hypothetical protein | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0035 | 1 | 1 |
| Echinococcus granulosus | g protein coupled receptor | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | serotonin receptor | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | 7TM GPCR, rhodopsin | 0.0035 | 1 | 1 |
| Echinococcus granulosus | tm gpcr rhodopsin | 0.0035 | 1 | 1 |
| Leishmania major | p450 reductase, putative | 0.0027 | 0.6294 | 1 |
| Onchocerca volvulus | 0.0035 | 1 | 0.5 | |
| Schistosoma mansoni | neuropeptide receptor | 0.0035 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | melatonin receptor type 1A | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | G-protein coupled receptor | 0.0035 | 1 | 1 |
| Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0027 | 0.6294 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | g-protein coupled receptor | 0.0035 | 1 | 1 |
| Echinococcus granulosus | g-protein coupled receptor | 0.0035 | 1 | 1 |
| Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0035 | 1 | 1 |
| Brugia malayi | Melatonin receptor type 1A | 0.0035 | 1 | 1 |
| Onchocerca volvulus | 0.0035 | 1 | 0.5 | |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 1 | 1 |
| Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0035 | 1 | 1 |
| Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0027 | 0.6294 | 0.5 |
| Echinococcus granulosus | neuropeptides capa receptor | 0.0035 | 1 | 1 |
| Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0035 | 1 | 1 |
| Echinococcus multilocularis | g protein coupled receptor | 0.0035 | 1 | 1 |
| Giardia lamblia | Hypothetical protein | 0.0024 | 0.4852 | 0.5 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0035 | 1 | 1 |
| Echinococcus granulosus | tm gpcr rhodopsin | 0.0035 | 1 | 1 |
| Schistosoma mansoni | opsin-like receptor | 0.0035 | 1 | 1 |
| Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0035 | 1 | 0.5 |
| Echinococcus multilocularis | fmrfamide receptor | 0.0035 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0035 | 1 | 1 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| IC50 (binding) | = 25 uM | Inhibition of rat brain recombinant nNOS | ChEMBL. | 18502134 |
| IC50 (binding) | = 30 uM | Inhibition of bovine recombinant eNOS | ChEMBL. | 18502134 |
| IC50 (binding) | = 110 uM | Inhibition of mouse recombinant iNOS | ChEMBL. | 18502134 |
| Inhibition (binding) | = 80 % | Inhibition of iNOS in LPS-stimulated Wistar rat lung assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion at 1 mM by liquid scintillation counting | ChEMBL. | 21334118 |
| Inhibition (binding) | = 88 % | Inhibition of nNOS in LPS-stimulated Wistar rat striata assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion at 1 mM by liquid scintillation counting | ChEMBL. | 21334118 |
| Ki (binding) | = 13 uM | Activity of rat brain recombinant nNOS assessed as L-arginine oxidation in presence of 10 uM (6R)-5,6,7,8-tetrahydro-L-biopterin | ChEMBL. | 18502134 |
Phenotypes
Whole-cell/tissue/organism interactions
We have no records of whole-cell/tissue assays done with this compound
What does this mean?
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
- ChEMBL: CHEMBL484298
Bibliographic References
1 literature reference was collected for this gene.
If you have references for this compound, please enter them in a user comment (below) or Contact us.