Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | phytoene synthase, CrtB | 0.099 | 0 | 0.5 |
Trypanosoma cruzi | squalene synthase, putative | 0.2039 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable phytoene synthase PhyA | 0.099 | 0 | 0.5 |
Trypanosoma cruzi | squalene synthase, putative | 0.2039 | 1 | 0.5 |
Trypanosoma brucei | squalene synthase, putative | 0.2039 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 56.9 uM | Antitrypanosomal activity against extracellular Trypanosoma cruzi Tulahuen clone C4 | ChEMBL. | 15497945 |
IC50 (functional) | = 95.5 uM | Antitrypanosomal activity against intracellular Trypanosoma cruzi Tulahuen clone C4 assessed as cleavage of chlorophenol red-beta-D-galactosidase | ChEMBL. | 15497945 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.