Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nmda type glutamate receptor | 0.0135 | 0.9755 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0042 | 0.0245 | 0.0251 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0042 | 0.0245 | 0.0251 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0096 | 0.5726 | 0.5869 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0135 | 0.9755 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0042 | 0.0245 | 0.0251 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0096 | 0.5726 | 0.5763 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0042 | 0.0245 | 0.0251 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0105 | 0.6644 | 0.6811 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0042 | 0.0245 | 0.0251 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0105 | 0.6644 | 0.6729 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antifungal activity against Candida albicans at 1 mM by almar blue dye reduction assay | ChEMBL. | 18585037 | |
Activity (functional) | Antifungal activity against Cryptococcus neoformans at 1 mM by almar blue dye reduction assay | ChEMBL. | 18585037 | |
Activity (functional) | Antifungal activity against Saccharomyces cerevisiae at 1 mM by almar blue dye reduction assay | ChEMBL. | 18585037 | |
Activity (functional) | Antibacterial activity against Escherichia coli at 1 mM by almar blue dye reduction assay | ChEMBL. | 18585037 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.