Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Cannabinoid CB1 receptor | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0125 | 0.1491 | 0.1683 |
Plasmodium falciparum | thioredoxin reductase | 0.0049 | 0 | 0.5 |
Mycobacterium leprae | Possible D-ribose-binding protein | 0.0264 | 0.4228 | 1 |
Onchocerca volvulus | 0.0058 | 0.0168 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0168 | 0.039 |
Plasmodium vivax | glutathione reductase, putative | 0.0049 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0113 | 0.1244 | 0.1404 |
Brugia malayi | O-methyltransferase family protein | 0.0058 | 0.0168 | 0.039 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.2509 | 0.5677 |
Brugia malayi | O-methyltransferase family protein | 0.0058 | 0.0168 | 0.039 |
Loa Loa (eye worm) | O-methyltransferase | 0.0058 | 0.0168 | 0.039 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.2509 | 0.5677 |
Schistosoma mansoni | glutaminase | 0.0268 | 0.4292 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0113 | 0.1244 | 0.1404 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0125 | 0.1491 | 0.1683 |
Mycobacterium tuberculosis | Probable methyltransferase | 0.0058 | 0.0168 | 0.0189 |
Wolbachia endosymbiont of Brugia malayi | O-methyltransferase | 0.0058 | 0.0168 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0049 | 0 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0125 | 0.1491 | 0.326 |
Treponema pallidum | methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-1) | 0.0264 | 0.4228 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0125 | 0.1491 | 0.1683 |
Echinococcus granulosus | geminin | 0.0177 | 0.2509 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.0268 | 0.4292 | 0.5 |
Loa Loa (eye worm) | glutaminase | 0.0268 | 0.4292 | 1 |
Mycobacterium ulcerans | glutaminase | 0.0268 | 0.4292 | 0.4195 |
Treponema pallidum | methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-2) | 0.0264 | 0.4228 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0113 | 0.1244 | 0.1404 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0113 | 0.1244 | 0.1404 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0049 | 0 | 0.5 |
Onchocerca volvulus | 0.0058 | 0.0168 | 0.5 | |
Brugia malayi | O-methyltransferase family protein | 0.0058 | 0.0168 | 0.039 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0113 | 0.1244 | 0.2652 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0049 | 0 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.0268 | 0.4292 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0049 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable catechol-O-methyltransferase | 0.05 | 0.8861 | 1 |
Brugia malayi | O-methyltransferase | 0.0058 | 0.0168 | 0.039 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0113 | 0.1244 | 0.1404 |
Leishmania major | trypanothione reductase | 0.0049 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0113 | 0.1244 | 0.1404 |
Echinococcus multilocularis | geminin | 0.0177 | 0.2509 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0268 | 0.4292 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0049 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.57 nM | Displacement of [3H]CP-55940 from CB1 receptor in Sprague-Dawley rat cerebellar membrane | ChEMBL. | 19022666 |
IC50 (binding) | > 10000 nM | Displacement of [3H]WIN-55212-2 from human CB2 receptor expressed in CHO cells | ChEMBL. | 19022666 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.