Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | checkpoint kinase 1 | Starlite/ChEMBL | References |
Homo sapiens | cyclin-dependent kinase 2 associated protein 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Schistosoma japonicum | Serine/threonine-protein kinase Chk1, putative | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_134982 | All targets in OG5_134982 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trichomonas vaginalis | WD repeat domain phosphoinositide-interacting protein, putative | cyclin-dependent kinase 2 associated protein 1 | 87 aa | 72 aa | 31.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0616 | 0.3226 | 0.3226 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1485 | 1 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.058 | 0.2945 | 0.2945 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.1485 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.058 | 0.2945 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1485 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.058 | 0.2945 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.1485 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.058 | 0.2945 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.058 | 0.2945 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.058 | 0.2945 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.1485 | 1 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.058 | 0.2945 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.058 | 0.2945 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.1485 | 1 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.1485 | 1 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.1485 | 1 | 0.5 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.058 | 0.2945 | 0.5 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0202 | 0 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.058 | 0.2945 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.1485 | 1 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.058 | 0.2945 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.1485 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1485 | 1 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.1485 | 1 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.1485 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.058 | 0.2945 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1485 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.34 uM | Abrogation of camptothecin induced cell cycle arrest at G2/M phase in human HT29 cells | ChEMBL. | 18547806 |
IC50 (binding) | = 0.004 uM | Inhibition of Chk1 | ChEMBL. | 18547806 |
IC50 (binding) | = 1.8 uM | Inhibition of Cdk1 | ChEMBL. | 18547806 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 18547806 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.