Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | DNA gyrase subunit B | 0.00818172 | 0.057749 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0157486 | 0.180305 | 0.716947 |
Loa Loa (eye worm) | carboxylesterase | 0.0273203 | 0.367725 | 1 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0187647 | 0.229155 | 0.623171 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0157486 | 0.180305 | 0.716947 |
Leishmania major | DNA topoisomerase IB, large subunit | 0.0187647 | 0.229155 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0273203 | 0.367725 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0141058 | 0.153697 | 0.417968 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.00818172 | 0.057749 | 0.0068166 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0133487 | 0.141436 | 0.491724 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0141058 | 0.153697 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0273203 | 0.367725 | 1 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0141058 | 0.153697 | 0.417968 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.00818172 | 0.057749 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0157486 | 0.180305 | 0.716947 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0187647 | 0.229155 | 0.623171 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0663583 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0273203 | 0.367725 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0141058 | 0.153697 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0273203 | 0.367725 | 1 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.0187647 | 0.229155 | 0.623171 |
Leishmania major | DNA topoisomerase ii | 0.0133487 | 0.141436 | 0.491724 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.00955664 | 0.0800177 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0141058 | 0.153697 | 0.562772 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0187647 | 0.229155 | 0.623171 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.00818172 | 0.057749 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00956988 | 0.0802321 | 0.218185 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0273203 | 0.367725 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.00955664 | 0.0800177 | 1 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0141058 | 0.153697 | 0.101829 |
Brugia malayi | DNA topoisomerase I | 0.0187647 | 0.229155 | 0.623171 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0663583 | 1 | 1 |
Onchocerca volvulus | Telomerase reverse transcriptase homolog | 0.00810909 | 0.0565725 | 0.707 |
Echinococcus granulosus | acetylcholinesterase | 0.0273203 | 0.367725 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.00955664 | 0.0800177 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0141058 | 0.153697 | 0.417968 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0141058 | 0.153697 | 0.417968 |
Loa Loa (eye worm) | hypothetical protein | 0.00578184 | 0.0188795 | 0.0513415 |
Loa Loa (eye worm) | hypothetical protein | 0.00956988 | 0.0802321 | 0.218185 |
Schistosoma mansoni | DNA topoisomerase II | 0.0141058 | 0.153697 | 0.417968 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0157486 | 0.180305 | 0.716947 |
Echinococcus multilocularis | acetylcholinesterase | 0.0273203 | 0.367725 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0133749 | 0.141859 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0133487 | 0.141436 | 0.491724 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0187647 | 0.229155 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0133487 | 0.141436 | 0.491724 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0273203 | 0.367725 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0141058 | 0.153697 | 0.417968 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0133487 | 0.141436 | 0.491724 |
Loa Loa (eye worm) | hypothetical protein | 0.00578184 | 0.0188795 | 0.0513415 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.0187647 | 0.229155 | 0.623171 |
Loa Loa (eye worm) | hypothetical protein | 0.0273203 | 0.367725 | 1 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.0187647 | 0.229155 | 0.623171 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0273203 | 0.367725 | 1 |
Plasmodium falciparum | topoisomerase I | 0.0187647 | 0.229155 | 0.181911 |
Loa Loa (eye worm) | hypothetical protein | 0.0273203 | 0.367725 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.00818172 | 0.057749 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0273203 | 0.367725 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0141058 | 0.153697 | 0.417968 |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.0187647 | 0.229155 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0141058 | 0.153697 | 0.101829 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.0187647 | 0.229155 | 1 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.00818172 | 0.057749 | 0.5 |
Plasmodium vivax | topoisomerase I, putative | 0.0187647 | 0.229155 | 0.181911 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.16 uM | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 after 72 hrs by microplate alamar blue assay | ChEMBL. | 18502136 |
IC50 (functional) | = 0.54 uM | Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs | ChEMBL. | 18502136 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei gambiense | 18502136 | ||
Plasmodium falciparum | ChEMBL23 | 18502136 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.