Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | gamma-aminobutyric acid (GABA) A receptor, alpha 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | gamma-aminobutyric acid (GABA) A receptor, alpha 1 | 456 aa | 451 aa | 30.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0775 | 0.6557 | 1 |
Brugia malayi | Fibulin-1 precursor | 0.0775 | 0.6557 | 0.6557 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0775 | 0.6557 | 0.6557 |
Echinococcus granulosus | Tolloid protein 1 | 0.0775 | 0.6557 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1026 | 1 | 1 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0775 | 0.6557 | 0.6557 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0775 | 0.6557 | 0.6557 |
Echinococcus multilocularis | fibrillin 1 | 0.0775 | 0.6557 | 1 |
Onchocerca volvulus | 0.1026 | 1 | 1 | |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0775 | 0.6557 | 0.6557 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0775 | 0.6557 | 0.6557 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0775 | 0.6557 | 0.6557 |
Schistosoma mansoni | egf-like domain protein | 0.0775 | 0.6557 | 0.6557 |
Loa Loa (eye worm) | hypothetical protein | 0.0775 | 0.6557 | 0.6557 |
Giardia lamblia | High cysteine protein | 0.0296 | 0 | 0.5 |
Onchocerca volvulus | Arrow homolog | 0.0775 | 0.6557 | 0.6557 |
Echinococcus granulosus | laminin | 0.0775 | 0.6557 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0775 | 0.6557 | 0.6557 |
Onchocerca volvulus | 0.0808 | 0.701 | 0.701 | |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0775 | 0.6557 | 1 |
Toxoplasma gondii | PAN domain-containing protein | 0.0581 | 0.39 | 0.5949 |
Loa Loa (eye worm) | hypothetical protein | 0.0775 | 0.6557 | 0.6557 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0775 | 0.6557 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0775 | 0.6557 | 0.6557 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1026 | 1 | 1 |
Toxoplasma gondii | PAN domain-containing protein | 0.0581 | 0.39 | 0.5949 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1026 | 1 | 1 |
Echinococcus multilocularis | laminin | 0.0775 | 0.6557 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0775 | 0.6557 | 0.6557 |
Loa Loa (eye worm) | hypothetical protein | 0.1026 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 11 nM | Displacement of [3H]flumazenil from human recombinant GABAA alpha-1-beta-2-gamma-2S receptor expressed in HEK293 cells | ChEMBL. | 18541432 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.