Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | histone deacetylase 7 | 0.0209 | 0.045 | 0.8842 |
Brugia malayi | Histone deacetylase family protein | 0.0209 | 0.045 | 0.8842 |
Echinococcus granulosus | histone deacetylase 6 | 0.0209 | 0.045 | 0.8842 |
Trypanosoma cruzi | UDP-galactose 4-epimerase, putative | 0.005 | 0.0045 | 0.0299 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0232 | 0.0509 | 1 |
Leishmania major | histone deacetylase, putative | 0.0209 | 0.045 | 0.8768 |
Entamoeba histolytica | UDP-glucose 4-epimerase, putative | 0.005 | 0.0045 | 0.0299 |
Onchocerca volvulus | 0.0037 | 0.0012 | 0.0723 | |
Plasmodium falciparum | histone deacetylase, putative | 0.0209 | 0.045 | 0.8768 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0209 | 0.045 | 0.8842 |
Plasmodium vivax | histone deacetylase, putative | 0.01 | 0.0171 | 0.2946 |
Loa Loa (eye worm) | UDP galactose 4'-epimerase | 0.005 | 0.0045 | 0.0883 |
Schistosoma mansoni | histone deacetylase | 0.0232 | 0.0509 | 1 |
Mycobacterium ulcerans | mycothiol conjugate amidase Mca | 0.3958 | 1 | 1 |
Loa Loa (eye worm) | phosphatidylinositol glycan anchor biosynthesis protein | 0.0045 | 0.0031 | 0.0602 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0232 | 0.0509 | 1 |
Brugia malayi | histone deacetylase 11 | 0.01 | 0.0171 | 0.3371 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0209 | 0.045 | 0.8842 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0209 | 0.045 | 0.8768 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0209 | 0.045 | 0.8768 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0082 | 0.0126 | 0.2001 |
Trichomonas vaginalis | NAD dependent epimerase/dehydratase, putative | 0.005 | 0.0045 | 0.0299 |
Mycobacterium tuberculosis | Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) | 0.3913 | 0.9887 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.0509 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0232 | 0.0509 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0232 | 0.0509 | 1 |
Brugia malayi | UDP galactose 4'-epimerase | 0.005 | 0.0045 | 0.0883 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0232 | 0.0509 | 1 |
Trypanosoma brucei | histone deacetylase 1 | 0.0232 | 0.0509 | 1 |
Plasmodium falciparum | histone deacetylase 1 | 0.0232 | 0.0509 | 1 |
Echinococcus granulosus | N acetylglucosaminyl phosphatidylinositol | 0.0045 | 0.0031 | 0.0602 |
Echinococcus multilocularis | N acetylglucosaminyl phosphatidylinositol | 0.0045 | 0.0031 | 0.0602 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.01 | 0.0171 | 0.2946 |
Schistosoma mansoni | disco-interacting protein 2 (dip2) | 0.0037 | 0.0012 | 0.0244 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.01 | 0.0171 | 0.2946 |
Brugia malayi | Uncharacterized LmbE-like protein, COG2120 containing protein | 0.0045 | 0.0031 | 0.0602 |
Trypanosoma brucei | histone deacetylase, putative | 0.0209 | 0.045 | 0.8768 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0215 | 0.0465 | 0.9142 |
Echinococcus multilocularis | histone deacetylase | 0.0209 | 0.045 | 0.8842 |
Leishmania major | histone deacetylase, putative | 0.0232 | 0.0509 | 1 |
Trichomonas vaginalis | UDP-glucose 4-epimerase, putative | 0.005 | 0.0045 | 0.0299 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0232 | 0.0509 | 1 |
Brugia malayi | Histone deacetylase 1 | 0.0232 | 0.0509 | 1 |
Trypanosoma brucei | histone deacetylase 4 | 0.0209 | 0.045 | 0.8768 |
Schistosoma mansoni | histone deacetylase | 0.0232 | 0.0509 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0232 | 0.0509 | 1 |
Echinococcus multilocularis | histone deacetylase 8 | 0.01 | 0.0171 | 0.3371 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0232 | 0.0509 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0209 | 0.045 | 0.8842 |
Trypanosoma cruzi | histone deacetylase, putative | 0.01 | 0.0171 | 0.2946 |
Trypanosoma cruzi | histone deacetylase, putative | 0.01 | 0.0171 | 0.2946 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.01 | 0.0171 | 0.3371 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0209 | 0.045 | 0.8768 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0232 | 0.0509 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0232 | 0.0509 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0209 | 0.045 | 0.8842 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0232 | 0.0509 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.0209 | 0.045 | 0.8768 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.01 | 0.0171 | 1 |
Echinococcus multilocularis | disco interacting protein 2 | 0.0037 | 0.0012 | 0.0244 |
Echinococcus granulosus | histone deacetylase 6 | 0.0209 | 0.045 | 0.8842 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.01 | 0.0171 | 0.3371 |
Echinococcus multilocularis | UDP glucose 4 epimerase | 0.005 | 0.0045 | 0.0883 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0012 | 0.0244 |
Schistosoma mansoni | UDP-glucose 4-epimerase | 0.005 | 0.0045 | 0.0883 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0215 | 0.0465 | 0.9142 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0209 | 0.045 | 0.8768 |
Leishmania major | histone deacetylase, putative | 0.0232 | 0.0509 | 1 |
Trypanosoma brucei | histone deacetylase 2 | 0.01 | 0.0171 | 0.2946 |
Trichomonas vaginalis | NAD dependent epimerase/dehydratase, putative | 0.005 | 0.0045 | 0.0299 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0232 | 0.0509 | 1 |
Leishmania major | histone deacetylase, putative | 0.0209 | 0.045 | 0.8768 |
Toxoplasma gondii | hypothetical protein | 0.0082 | 0.0126 | 0.2001 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0232 | 0.0509 | 1 |
Echinococcus granulosus | histone deacetylase 8 | 0.01 | 0.0171 | 0.3371 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0211 | 0.4144 |
Plasmodium vivax | histone deacetylase, putative | 0.0209 | 0.045 | 0.8768 |
Echinococcus granulosus | disco interacting protein 2 | 0.0037 | 0.0012 | 0.0244 |
Giardia lamblia | UDP-glucose 4-epimerase | 0.0048 | 0.004 | 0.0205 |
Plasmodium falciparum | histone deacetylase 2 | 0.0209 | 0.045 | 0.8768 |
Echinococcus granulosus | histone deacetylase 6 | 0.0215 | 0.0465 | 0.9142 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0209 | 0.045 | 0.8842 |
Brugia malayi | Disco-interacting protein 2 homolog | 0.0037 | 0.0012 | 0.0244 |
Schistosoma mansoni | N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase | 0.0045 | 0.0031 | 0.0602 |
Echinococcus granulosus | UDP glucose 4 epimerase | 0.005 | 0.0045 | 0.0883 |
Entamoeba histolytica | histone deacetylase, putative | 0.0232 | 0.0509 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0196 | 0.3845 |
Loa Loa (eye worm) | histone deacetylase | 0.0209 | 0.045 | 0.8842 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0209 | 0.045 | 0.8768 |
Trypanosoma brucei | UDP-galactose 4-epimerase | 0.0048 | 0.004 | 0.0205 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0232 | 0.0509 | 1 |
Trypanosoma cruzi | UDP-galactose 4-epimerase | 0.005 | 0.0045 | 0.0299 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0232 | 0.0509 | 1 |
Toxoplasma gondii | UDP-glucose 4-epimerase | 0.005 | 0.0045 | 0.0299 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0232 | 0.0509 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0209 | 0.045 | 0.8842 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0232 | 0.0509 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0232 | 0.0509 | 1 |
Echinococcus granulosus | histone deacetylase | 0.0209 | 0.045 | 0.8842 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0171 | 0.3371 |
Echinococcus granulosus | histone deacetylase 3 | 0.0232 | 0.0509 | 1 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0232 | 0.0509 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.01 | 0.0171 | 0.3371 |
Giardia lamblia | Histone deacetylase | 0.0232 | 0.0509 | 1 |
Leishmania major | udp-glc 4-epimerase, putative | 0.0048 | 0.004 | 0.0205 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0209 | 0.045 | 0.8842 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0232 | 0.0509 | 1 |
Echinococcus granulosus | histone deacetylase 1 | 0.0232 | 0.0509 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.