Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | adenosine kinase | 0.1675 | 1 | 1 |
Trypanosoma brucei | adenosine kinase, putative | 0.1675 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1675 | 1 | 1 |
Onchocerca volvulus | 0.1484 | 0.869 | 0.5 | |
Echinococcus multilocularis | adenosine kinase | 0.1675 | 1 | 0.5 |
Schistosoma mansoni | adenosine kinase | 0.1675 | 1 | 1 |
Trypanosoma brucei | adenosine kinase, putative | 0.1675 | 1 | 0.5 |
Leishmania major | adenosine kinase, putative | 0.1675 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.0693 | 0.0693 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0319 | 0.0693 | 0.0693 |
Trypanosoma cruzi | adenosine kinase, putative | 0.1675 | 1 | 0.5 |
Toxoplasma gondii | kinase, pfkB family protein | 0.1675 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0319 | 0.0693 | 0.0693 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0319 | 0.0693 | 0.0693 |
Echinococcus granulosus | adenosine kinase | 0.1675 | 1 | 0.5 |
Trypanosoma cruzi | adenosine kinase, putative | 0.1675 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0 % | Angiotensin II-like agonist activity, measured in the in vitro rabbit aorta strip assay | ChEMBL. | 2724307 |
Blood pressure (functional) | = 5 mmHg | In vivo blood pressure increase produced by a 1 ug bolus i.v. | ChEMBL. | 2724307 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.