Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1414 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0049 | 0 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0049 | 0 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0049 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0125 | 0.0555 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1414 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0049 | 0 | 0.5 |
Leishmania major | trypanothione reductase | 0.0049 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0113 | 0.0463 | 0.8342 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0125 | 0.0555 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0113 | 0.0463 | 0.8342 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0913 | 0.6324 | 0.6008 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0113 | 0.0463 | 0.8342 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.3162 | 0.3162 |
Brugia malayi | glutathione reductase | 0.0049 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0113 | 0.0463 | 0.8342 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0113 | 0.0463 | 0.8342 |
Plasmodium falciparum | glutathione reductase | 0.0049 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0113 | 0.0463 | 0.8342 |
Loa Loa (eye worm) | hypothetical protein | 0.0432 | 0.2801 | 0.2801 |
Plasmodium vivax | glutathione reductase, putative | 0.0049 | 0 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0125 | 0.0555 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0125 | 0.0555 | 1 |
Schistosoma mansoni | calcium-activated potassium channel | 0.1414 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0455 | 0.2972 | 0.2972 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0846 | 0.5837 | 0.5837 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.1414 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.