Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phospholipase D1, phosphatidylcholine-specific | Starlite/ChEMBL | References |
Homo sapiens | phospholipase D2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | phospholipase D active site domain-containing protein | 0.0043 | 0.1973 | 0.5 |
Leishmania major | phosphatidylglycerophosphate synthase, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.8027 | 1 |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.0043 | 0.1973 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.5702 | 0.7103 |
Echinococcus multilocularis | phospholipase D | 0.011 | 0.8562 | 0.8562 |
Echinococcus granulosus | phospholipase D1 | 0.0124 | 1 | 1 |
Trypanosoma brucei | cardiolipin synthetase, putative | 0.0043 | 0.1973 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.5702 | 0.7103 |
Onchocerca volvulus | Putative phospholipase D | 0.0023 | 0 | 0.5 |
Entamoeba histolytica | phospholipase D, putative | 0.0124 | 1 | 1 |
Schistosoma mansoni | phospholipase D | 0.0124 | 1 | 0.5 |
Echinococcus multilocularis | phospholipase D1 | 0.0124 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.8027 | 1 |
Entamoeba histolytica | phospholipase D, putative | 0.0124 | 1 | 1 |
Brugia malayi | Phospholipase D. Active site motif family protein | 0.0043 | 0.1973 | 0.1973 |
Trypanosoma brucei | cardiolipin synthetase | 0.0043 | 0.1973 | 0.5 |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.0043 | 0.1973 | 0.5 |
Echinococcus granulosus | phospholipase D | 0.011 | 0.8562 | 0.8562 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.