Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3304 | 0.3304 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3304 | 0.3304 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.3304 | 0.3304 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0032 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0032 | 1 | 1 |
Onchocerca volvulus | 0.0032 | 1 | 0.5 | |
Entamoeba histolytica | aldose reductase, putative | 0.0032 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0032 | 1 | 1 |
Onchocerca volvulus | 0.0032 | 1 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0032 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0032 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0032 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0032 | 1 | 1 |
Echinococcus multilocularis | aldehyde reductase | 0.0023 | 0.4977 | 0.2499 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0032 | 1 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.0032 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0032 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0032 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0032 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0032 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0032 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0032 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0032 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0032 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0032 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0032 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.3304 | 0.3304 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3304 | 0.3304 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0032 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.3304 | 0.3304 |
Onchocerca volvulus | 0.0032 | 1 | 0.5 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3304 | 0.3304 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0032 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0032 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0032 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0032 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0032 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0032 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0032 | 1 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0032 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0032 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3304 | 0.3304 |
Schistosoma mansoni | aldo-keto reductase | 0.0032 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0032 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0032 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0032 | 1 | 1 |
Onchocerca volvulus | 0.0032 | 1 | 0.5 | |
Schistosoma mansoni | pol-related | 0.0032 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3304 | 0.3304 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0032 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0032 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0032 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0032 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0032 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3304 | 0.3304 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0032 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0032 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0032 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0032 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3304 | 0.3304 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.002 | 0.3304 | 0.3304 |
Trypanosoma brucei | prostaglandin f synthase | 0.0032 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0032 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0032 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0032 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0032 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0032 | 1 | 1 |
Trypanosoma cruzi | aldo-keto reductase | 0.0032 | 1 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0032 | 1 | 1 |
Onchocerca volvulus | 0.0032 | 1 | 0.5 | |
Leishmania major | aldo-keto reductase-like protein | 0.0032 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0032 | 1 | 1 |
Onchocerca volvulus | 0.0032 | 1 | 0.5 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3304 | 0.3304 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0032 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0032 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3304 | 0.3304 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0032 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0032 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0032 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0032 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0032 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0032 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0032 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0032 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0032 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0032 | 1 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0032 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0032 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.002 | 0.3304 | 0.3304 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0032 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0032 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0032 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0032 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0032 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0032 | 1 | 1 |
Echinococcus granulosus | aldehyde reductase | 0.0023 | 0.4977 | 0.2499 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | > 100 uM | Cytotoxicity against mock-infected human MT4 cells by MTT assay | ChEMBL. | 18226533 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.