Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0024 | 1 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0021 | 0.2086 | 0.2086 |
Plasmodium vivax | RNA helicase-1, putative | 0.0024 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.2086 | 0.2086 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0024 | 1 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0024 | 1 | 1 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0024 | 1 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0024 | 1 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0024 | 1 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0024 | 1 | 0.5 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0021 | 0.2086 | 0.2086 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0024 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0024 | 1 | 0.5 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0024 | 1 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0021 | 0.2086 | 0.2086 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0024 | 1 | 0.5 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0024 | 1 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0024 | 1 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0021 | 0.2086 | 0.2086 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 1 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0024 | 1 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0021 | 0.2086 | 0.2086 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0024 | 1 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0024 | 1 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0021 | 0.2086 | 0.2086 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0024 | 1 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0024 | 1 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0024 | 1 | 0.5 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0024 | 1 | 0.5 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0024 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 1 uM | Growth inhibition of human K562 cells expressing p210Bcr/Abl after 96 hrs by trypan blue exclusion assay | ChEMBL. | 20188579 |
GI50 (functional) | = 1 uM | Growth inhibition of human DU145 cells after 96 hrs by trypan blue exclusion assay | ChEMBL. | 20188579 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.