Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epidermal growth factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | prolyl oligopeptidase | 0.019 | 0.5251 | 0.5251 |
Echinococcus multilocularis | insulin receptor | 0.0058 | 0.032 | 0.0134 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0064 | 0.056 | 0.5 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.018 | 0.4868 | 0.4868 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0064 | 0.056 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0058 | 0.032 | 0.0134 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0064 | 0.056 | 0.5 |
Echinococcus multilocularis | geminin | 0.0169 | 0.4461 | 0.8419 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0064 | 0.056 | 0.0487 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0058 | 0.032 | 0.032 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0097 | 0.1775 | 0.3046 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.4461 | 0.8397 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.1737 | 0.2874 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.4461 | 0.8397 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.1775 | 0.2951 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.018 | 0.4868 | 0.4868 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.1737 | 0.2874 |
Echinococcus granulosus | epidermal growth factor receptor | 0.018 | 0.4868 | 0.9223 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0097 | 0.1775 | 0.2951 |
Brugia malayi | Protein kinase domain containing protein | 0.0058 | 0.032 | 0.032 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0064 | 0.056 | 0.0615 |
Schistosoma mansoni | tyrosine kinase | 0.018 | 0.4868 | 0.9223 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.019 | 0.5251 | 0.5 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.019 | 0.5251 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.019 | 0.5251 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.019 | 0.5251 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.1775 | 0.2951 |
Brugia malayi | prolyl oligopeptidase family protein | 0.019 | 0.5251 | 0.5251 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.1737 | 0.2874 |
Toxoplasma gondii | 1,3-beta-glucan synthase component protein | 0.0213 | 0.6071 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0064 | 0.056 | 0.056 |
Loa Loa (eye worm) | STAT protein | 0.0318 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.018 | 0.4868 | 0.9233 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0064 | 0.056 | 0.0487 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0064 | 0.056 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0097 | 0.1775 | 0.2951 |
Echinococcus granulosus | geminin | 0.0169 | 0.4461 | 0.8397 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0064 | 0.056 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9.1 | Inhibition of human recombinant EGFR | ChEMBL. | 19170633 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.