Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Effect on c-Akt phosphorylation in in human LNCAP cells | ChEMBL. | 20805033 | |
Activity (binding) | Effect on p38 phosphorylation in in human LNCAP cells | ChEMBL. | 20805033 | |
Activity (functional) | Increase of NRF2-mediated NQO-1 expression in hormone-refractory human DU145 cells at 5 uM after 24 hrs by Western blotting | ChEMBL. | 20805033 | |
Activity (functional) | Increase of NRF2-mediated NQO-1 expression in human LNCaP cells at 5 uM after 24 hrs by Western blotting | ChEMBL. | 20805033 | |
Activity (functional) | Induction of nuclear translocation of NRF2 in human LNCaP cells at 5 uM after 0.5 hrs by Western blotting | ChEMBL. | 20805033 | |
Activity (functional) | Induction of nuclear translocation of NRF2 in human LNCaP cells at 5 uM after 6 hrs by Western blotting | ChEMBL. | 20805033 | |
Activity (functional) | Increase of NRF2-mediated HO-1 expression in hormone-refractory human MDA-MB-231 cells after 24 hrs by Western blotting | ChEMBL. | 20805033 | |
Activity (functional) | Increase of NRF2-mediated HO-1 expression in human LNCaP cells after 24 hrs by Western blotting | ChEMBL. | 20805033 | |
Activity (functional) | Increase of NRF2-mediated NQO-1 expression in hormone-refractory human PC3 cells at 5 uM after 24 hrs by Western blotting | ChEMBL. | 20805033 | |
Activity (functional) | Increase of NRF2-mediated HO-1 expression in hormone-refractory human MCF7 cells after 24 hrs by Western blotting | ChEMBL. | 20805033 | |
Activity (functional) | Increase of NRF2-mediated HO-1 expression in hormone-refractory human PC3 cells at 5 uM after 24 hrs by Western blotting | ChEMBL. | 20805033 | |
Activity (functional) | Increase of NRF2-mediated HO-1 expression in human LNCaP cells at 5 uM after 24 hrs by Western blotting | ChEMBL. | 20805033 | |
Activity (functional) | Increase of NRF2-mediated HO-1 expression in human LNCaP cells at 5 uM by Western blotting | ChEMBL. | 20805033 | |
Activity (functional) | Increase of NRF2-mediated HO-1 expression in hormone-refractory human DU145 cells at 5 uM after 24 hrs by Western blotting | ChEMBL. | 20805033 | |
FC (functional) | < 2 | Induction of NRF2-mediated ARE enhancer activity in hormone-refractory human DU145 cells transfected with pGL3-ARE-TK-luc at 5 uM after 24 hrs by luciferase assay relative to control | ChEMBL. | 20805033 |
FC (functional) | < 2 | Induction of NRF2-mediated ARE enhancer activity in hormone-refractory human PC3 cells transfected with pGL3-ARE-TK-luc at 5 uM after 24 hrs by luciferase assay relative to control | ChEMBL. | 20805033 |
FC (functional) | = 6 | Induction of NRF2-mediated ARE enhancer activity in hormone-sensitive human LNCaP cells transfected with pGL3-ARE-TK-luc at 5 uM after 24 hrs by luciferase assay relative to control | ChEMBL. | 20805033 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.