Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | dynamin-related protein DRPB | 0.00578919 | 0.811199 | 1 |
Entamoeba histolytica | dynamin-like protein | 0.00578919 | 0.811199 | 0.5 |
Plasmodium vivax | dynamin-like protein, putative | 0.00578919 | 0.811199 | 0.5 |
Echinococcus granulosus | dynamin 1 | 0.00623214 | 1 | 1 |
Leishmania major | GTP-binding protein, putative | 0.00578919 | 0.811199 | 0.5 |
Echinococcus multilocularis | dynamin 1 | 0.00623214 | 1 | 1 |
Trichomonas vaginalis | dynamin, putative | 0.00578919 | 0.811199 | 0.5 |
Entamoeba histolytica | dynamin-1-like protein, putative | 0.00578919 | 0.811199 | 0.5 |
Plasmodium vivax | dynamin protein, putative | 0.00578919 | 0.811199 | 0.5 |
Trichomonas vaginalis | dynamin, putative | 0.00578919 | 0.811199 | 0.5 |
Trichomonas vaginalis | mgm1, putative | 0.00578919 | 0.811199 | 0.5 |
Trypanosoma brucei | dynamin-1-like protein | 0.00578919 | 0.811199 | 0.5 |
Trypanosoma brucei | dynamin-1-like protein | 0.00578919 | 0.811199 | 0.5 |
Brugia malayi | Dynamin | 0.00623214 | 1 | 1 |
Trichomonas vaginalis | dynamin, putative | 0.00578919 | 0.811199 | 0.5 |
Schistosoma mansoni | dynamin | 0.00623214 | 1 | 1 |
Plasmodium falciparum | dynamin-like protein | 0.00578919 | 0.811199 | 0.5 |
Giardia lamblia | Dynamin | 0.00578919 | 0.811199 | 0.5 |
Plasmodium falciparum | dynamin-like protein | 0.00578919 | 0.811199 | 0.5 |
Trichomonas vaginalis | interferon-induced GTP-binding protein mx, putative | 0.00578919 | 0.811199 | 0.5 |
Trichomonas vaginalis | dynamin, putative | 0.00578919 | 0.811199 | 0.5 |
Trichomonas vaginalis | dynamin, putative | 0.00578919 | 0.811199 | 0.5 |
Trichomonas vaginalis | dynamin, putative | 0.00578919 | 0.811199 | 0.5 |
Brugia malayi | Dynamin | 0.00623214 | 1 | 1 |
Schistosoma mansoni | dynamin | 0.00623214 | 1 | 1 |
Trypanosoma cruzi | dynamin-1-like protein | 0.00578919 | 0.811199 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00623214 | 1 | 1 |
Toxoplasma gondii | dynamin-related protein DRPA | 0.00578919 | 0.811199 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.79 ug ml-1 | Antiplasmodial activity against Plasmodium falciparum NF54 in human erythrocytes by [3H]hypoxanthine uptake | ChEMBL. | 11087584 |
IC50 (functional) | = 2.03 ug ml-1 | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 by Alamar blue assay | ChEMBL. | 11087584 |
IC50 (functional) | = 10 ug ml-1 | Antileishmanial activity against Leishmania donovani MHOM-ET-67/L82 amastigotes in mouse peritoneal macrophages | ChEMBL. | 11087584 |
IC50 (functional) | = 17.6 ug ml-1 | Antitrypanosomal activity against galactosidase gene containing Trypanosoma cruzi Tulahuen C2C4 trypomastigotes in rat L6 cells after 4 days | ChEMBL. | 11087584 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 11087584 | |
Leishmania donovani | ChEMBL23 | 11087584 | |
Trypanosoma brucei gambiense | 11087584 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.