Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0739 | 0.5 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0739 | 0.5 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0739 | 0.5 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0739 | 0.5 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0739 | 0.5 | 0.5 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0739 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0739 | 0.5 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0739 | 0.5 | 0.5 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0739 | 0.5 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0739 | 0.5 | 0.5 |
Plasmodium vivax | RNA helicase-1, putative | 0.0739 | 0.5 | 0.5 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0739 | 0.5 | 0.5 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0739 | 0.5 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0739 | 0.5 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0739 | 0.5 | 0.5 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0739 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0739 | 0.5 | 0.5 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0739 | 0.5 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0739 | 0.5 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0739 | 0.5 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0739 | 0.5 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0739 | 0.5 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0739 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900 | ChEMBL. | 19010569 | |
IC50 (functional) | = 0.211 ug ml-1 | Antiparasitic activity against Plasmodium falciparum K1 | ChEMBL. | 19010569 |
Inhibition (functional) | <= 50 % | Antiparasitic activity against Leishmania donovani MHOM-ET/67/L82 at 0.81 ug/ml | ChEMBL. | 19010569 |
Inhibition (functional) | <= 50 % | Antiparasitic activity against Trypanosoma cruzi Tulahuen C4 containing lacz gene at 0.81 ug/ml | ChEMBL. | 19010569 |
Inhibition (functional) | <= 70 % | Antiparasitic activity against Leishmania donovani MHOM-ET/67/L82 at 4.85 ug/ml | ChEMBL. | 19010569 |
Inhibition (functional) | <= 70 % | Antiparasitic activity against Trypanosoma cruzi Tulahuen C4 containing lacz gene at 4.85 ug/ml | ChEMBL. | 19010569 |
MIC (functional) | = 3.12 ug ml-1 | Antifungal activity against Candida albicans ATCC 10231 by macro-broth dilution method | ChEMBL. | 19010569 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | 19010569 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.