Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | eukaryotic translation initiation factor 2 alpha | 0.1564 | 1 | 1 |
Loa Loa (eye worm) | PEK/HRI protein kinase | 0.1564 | 1 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0043 | 0.0029 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.1564 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.1564 | 1 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0043 | 0.0029 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0029 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.1564 | 1 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0043 | 0.0029 | 0.5 |
Trypanosoma brucei | eukaryotic translation initiation factor 2-alpha kinase 1, putative | 0.1564 | 1 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0043 | 0.0029 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0029 | 0.5 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0038 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0196 | 0.1035 | 0.1008 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 0.1035 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0043 | 0.0029 | 0.5 |
Echinococcus granulosus | eukaryotic translation initiation factor 2 alpha | 0.1564 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0196 | 0.1035 | 0.1008 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0043 | 0.0029 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 0.1035 | 1 |
Leishmania major | protein kinase, putative | 0.1564 | 1 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0038 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 200 uM | Inhibition of Mycobacterium tuberculosis cloned 1-deoxy-D-xylulose-5-phosphate synthase expressed in Escherichia coli | ChEMBL. | 18783951 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.