Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | geminin | 0.0267 | 1 | 1 |
Schistosoma mansoni | ets-related | 0.0164 | 0.5542 | 0.5542 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0742 | 0.134 |
Loa Loa (eye worm) | potassium voltage-gated channel subfamily Q member 5 | 0.0057 | 0.088 | 0.1588 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0086 | 0.215 | 0.1514 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0086 | 0.215 | 0.388 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0742 | 0.134 |
Brugia malayi | Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog | 0.0127 | 0.3917 | 0.7068 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0086 | 0.215 | 0.388 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0054 | 0.075 | 0.1353 |
Echinococcus granulosus | potassium channel KvQLT family member kqt 1 | 0.0127 | 0.3917 | 0.3424 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0742 | 0.134 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0408 | 0.0737 |
Echinococcus granulosus | potassium voltage gated channel subfamily KQT | 0.0057 | 0.088 | 0.0141 |
Brugia malayi | Ets-domain containing protein | 0.0054 | 0.075 | 0.1353 |
Schistosoma mansoni | hypothetical protein | 0.0267 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.088 | 0.1588 |
Schistosoma mansoni | hypothetical protein | 0.0267 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0086 | 0.215 | 0.1514 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.0125 | 0.3824 | 0.69 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0086 | 0.215 | 0.215 |
Loa Loa (eye worm) | fli-1 protein | 0.0164 | 0.5542 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0742 | 0.134 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0086 | 0.215 | 0.1514 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.0127 | 0.3917 | 0.3424 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.088 | 0.1588 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0086 | 0.215 | 0.215 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0086 | 0.215 | 0.215 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.0057 | 0.088 | 0.0141 |
Schistosoma mansoni | gabp alpha | 0.0054 | 0.075 | 0.075 |
Brugia malayi | Ets-domain containing protein | 0.0054 | 0.075 | 0.1353 |
Schistosoma mansoni | voltage-gated potassium channel KCNQ | 0.0127 | 0.3917 | 0.3917 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0086 | 0.215 | 0.1514 |
Brugia malayi | Fli-1 protein | 0.0164 | 0.5542 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 3 ug ml-1 | Cytotoxicity against human KB cells | ChEMBL. | 469554 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.