Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | phospholipase D1 | 0.1754 | 1 | 1 |
Schistosoma mansoni | phospholipase D | 0.1754 | 1 | 0.5 |
Entamoeba histolytica | phospholipase D, putative | 0.1754 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1142 | 0.5702 | 0.7103 |
Onchocerca volvulus | Putative phospholipase D | 0.0331 | 0 | 0.5 |
Echinococcus multilocularis | phospholipase D | 0.1549 | 0.8562 | 0.8562 |
Trypanosoma brucei | cardiolipin synthetase, putative | 0.0612 | 0.1973 | 0.5 |
Echinococcus granulosus | phospholipase D1 | 0.1754 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1142 | 0.5702 | 0.7103 |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.0612 | 0.1973 | 0.5 |
Toxoplasma gondii | phospholipase D active site domain-containing protein | 0.0612 | 0.1973 | 0.5 |
Leishmania major | phosphatidylglycerophosphate synthase, putative | 0.0331 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1473 | 0.8027 | 1 |
Echinococcus granulosus | phospholipase D | 0.1549 | 0.8562 | 0.8562 |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.0612 | 0.1973 | 0.5 |
Trypanosoma brucei | cardiolipin synthetase | 0.0612 | 0.1973 | 0.5 |
Brugia malayi | Phospholipase D. Active site motif family protein | 0.0612 | 0.1973 | 0.1973 |
Entamoeba histolytica | phospholipase D, putative | 0.1754 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1473 | 0.8027 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.