Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.6999 | 0.9546 |
Brugia malayi | bZIP transcription factor family protein | 0.0083 | 0.2689 | 0.2689 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0136 | 0.516 | 0.7372 |
Schistosoma mansoni | single-minded | 0.0063 | 0.1755 | 0.2393 |
Echinococcus granulosus | single minded 2 | 0.0047 | 0.0992 | 0.1417 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.4397 | 0.4397 |
Brugia malayi | hypothetical protein | 0.0065 | 0.1858 | 0.1858 |
Echinococcus multilocularis | jun protein | 0.0083 | 0.2689 | 0.3841 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.2583 | 0.2583 |
Brugia malayi | aryl hydrocarbon receptor AHR-1 | 0.0119 | 0.4371 | 0.4371 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.024 | 1 | 1 |
Brugia malayi | PAS domain containing protein | 0.0063 | 0.1755 | 0.1755 |
Echinococcus granulosus | geminin | 0.0175 | 0.6999 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.1964 | 0.2678 |
Onchocerca volvulus | 0.0065 | 0.1858 | 0.3618 | |
Mycobacterium ulcerans | putative regulatory protein | 0.0047 | 0.0992 | 0.5 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0183 | 0.7332 | 1 |
Schistosoma mansoni | jun-related protein | 0.0067 | 0.1964 | 0.2678 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0136 | 0.516 | 0.7372 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.6999 | 0.9546 |
Echinococcus multilocularis | geminin | 0.0175 | 0.6999 | 1 |
Brugia malayi | bHLH-PAS transcription factor | 0.0047 | 0.0992 | 0.0992 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.5134 | 0.5134 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0083 | 0.2689 | 0.3841 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.4371 | 0.4371 |
Onchocerca volvulus | 0.0135 | 0.5134 | 1 | |
Echinococcus multilocularis | transfer RNA-Lys | 0.0047 | 0.0992 | 0.1417 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0083 | 0.2689 | 0.3841 |
Echinococcus granulosus | jun protein | 0.0083 | 0.2689 | 0.3841 |
Onchocerca volvulus | 0.0047 | 0.1017 | 0.1981 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.