Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.0466 | 0.4772 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.083 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.083 | 1 | 0.5 |
Onchocerca volvulus | 0.0759 | 0.8973 | 0.741 | |
Trypanosoma brucei | ferric reductase transmembrane protein, putative | 0.0466 | 0.4772 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.083 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0133 | 0 | 0.5 |
Leishmania major | ferric reductase, putative | 0.0466 | 0.4772 | 0.5 |
Treponema pallidum | hypothetical protein | 0.0133 | 0 | 0.5 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.0466 | 0.4772 | 0.5 |
Onchocerca volvulus | 0.083 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.083 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 23.8 uM | Inhibition of mushroom tyrosinase after 25 mins by spectrophotometry | ChEMBL. | 21377874 |
IC50 (binding) | > 300 uM | Inhibition of yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate preincubated for 10 min before substrate addition and measured after 10 min by spectrophotometry | ChEMBL. | No reference |
Inhibition (binding) | Inhibition of yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate preincubated for 10 min before substrate addition and measured after 10 min by spectrophotometry | ChEMBL. | No reference | |
Inhibition (binding) | = 6.5 % | Inhibition of COX2 at 400 uM after 5 mins by spectrophotometric analysis | ChEMBL. | 22386242 |
Inhibition (binding) | = 21.3 % | Inhibition of COX1 at 400 uM after 5 mins by spectrophotometric analysis | ChEMBL. | 22386242 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.