Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Matrilysin homolog | 0.0047 | 0.0426 | 1 |
Brugia malayi | Matrixin family protein | 0.0051 | 0.0511 | 0.0511 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0269 | 0.4929 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0047 | 0.0426 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0026 | 0 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.003 | 0.0085 | 0.0085 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0269 | 0.4929 | 0.4886 |
Schistosoma mansoni | serine/threonine protein kinase | 0.052 | 1 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase I | 0.0269 | 0.4927 | 0.9994 |
Entamoeba histolytica | protein kinase, putative | 0.0269 | 0.4929 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.005 | 0.0493 | 0.0411 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.052 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0269 | 0.4929 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.0026 | 0 | 0.5 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase I | 0.0269 | 0.4927 | 0.9994 |
Echinococcus granulosus | serine:threonine protein kinase Chk2 | 0.0269 | 0.4929 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0047 | 0.0426 | 0.0426 |
Loa Loa (eye worm) | matrixin family protein | 0.0051 | 0.0511 | 0.0511 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0026 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.