Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.0442 | 0.0442 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.0442 | 0.0442 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0107 | 0.0442 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.0442 | 0.0442 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0107 | 0.0442 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.1203 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.0442 | 0.0442 |
Plasmodium vivax | NIMA-related protein kinase (Pfnek-1), putative | 0.1203 | 1 | 0.5 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0107 | 0.0442 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.0442 | 0.0442 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0107 | 0.0442 | 0.5 |
Plasmodium falciparum | NIMA related kinase 1 | 0.1203 | 1 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0107 | 0.0442 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.1203 | 1 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0107 | 0.0442 | 0.5 |
Giardia lamblia | Kinase, NEK | 0.1203 | 1 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0107 | 0.0442 | 0.5 |
Giardia lamblia | Kinase, NEK | 0.1203 | 1 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0107 | 0.0442 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0107 | 0.0442 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.0442 | 0.0442 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.0442 | 0.0442 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0107 | 0.0442 | 1 |
Toxoplasma gondii | NIMA-related protein kinase NIMA1 | 0.1203 | 1 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0107 | 0.0442 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 30 % | Cytotoxicity against human KB cells at 10 ug/mL | ChEMBL. | 12502324 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.