Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glycogen phosphorylase | 0.0213 | 0.5 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0213 | 0.5 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0213 | 0.5 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0213 | 0.5 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.0213 | 0.5 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0213 | 0.5 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0213 | 0.5 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0213 | 0.5 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0213 | 0.5 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0213 | 0.5 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0213 | 0.5 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0213 | 0.5 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0213 | 0.5 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0213 | 0.5 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0213 | 0.5 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0213 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 50 uM | Inhibition of histidine-tagged human recombinant Cdc25B catalytic domain expressed in Escherichia coli | ChEMBL. | 19028102 |
IC50 (binding) | > 50 uM | Inhibition of histidine-tagged mouse MKP1 catalytic domain expressed in human Hela cells | ChEMBL. | 19028102 |
IC50 (binding) | > 50 uM | Inhibition of histidine-tagged rat recombinant MKP3 catalytic domain expressed in Escherichia coli BL21(DE3) | ChEMBL. | 19028102 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.